Pathophysiology of pregnancy-induced hypertension

American Journal of Hypertension

Volumn 14, Issue 6 II, 2001, Pages

  Granger, Joey P ^a,b   Alexander, Barbara T ^a   Bennett, William A ^a   Khalil, Raouf A ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Blood pressure; Endothelium; Kidney; Placental ischemia

Indexed keywords

ANGIOTENSIN; ENDOTHELIN; NITRIC OXIDE; PROSTACYCLIN; THROMBOXANE;

ARTERIAL PRESSURE; CONFERENCE PAPER; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; MATERNAL HYPERTENSION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PLACENTA CIRCULATION; PRIORITY JOURNAL;

EID: 0034988987     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0895-7061(01)02086-6     Document Type: Conference Paper

References (67)

1. Pathophysiology of preeclampsia
2. Renal physiology and disease in pregnancy
3. Epidemiology of preeclampsia and eclampsia in the United States, 1979-1986
4. Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation
5. Animal models of pre-eclampsia: Do they exist?
6. The rat as a model for preeclampsia
7. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia
8. Nitric oxide, the endothelium, pregnancy and pre-eclampsia
9. Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells
10. Beneficial effects of U-63, 557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension
11. Glomerular filtration during and after pregnancy
12. A study of angiotensin II pressor response throughout primigravid pregnancy
13. Possible mechanisms for changes in renal hemodynamics during pregnancy: Studies from animal models
14. Importance of nitric oxide in control of systemic and renal hemodynamics during normal pregnancy: Studies in the rat and implications for preeclampsia
15. Increased peripheral resistance during reduced uterine perfusion pressure hypertension in pregnant rabbits
16. A role for brain angiotensin II in experimental pregnancy-induced hypertension in laboratory rats
17. Simplified technique to produce toxemia in the rat: Consideration on cause of toxemia
18. Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide
19. Adaptation of the uterine arcade in rats during pregnancy
20. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rats
21. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats
22. Pathophysiology of pregnancy-induced hypertension
23. Abnormal pressure natriuresis in hypertension: Role of nitric oxide
24. The role of nitric oxide in the pathogenesis of preeclampsia
25. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat
26. NO in the kidney: Synthesis, localization and function
27. Role of renal interstitial pressure as a mediator of sodium retention during blockade of endothelium derived nitric oxide hypertension
28. Renal hemodynamic effects of angiotensin II (AII): Interactions with endothelium derived nitric oxide
29. Role of nitric oxide in modulating the vasoconstrictor actions of angiotensin II in preglomerular and postglomerular vessels in dogs
30. Role of nitric oxide in mediating the reduced sensitivity of the renal circulation to angiotensin II in pregnant rats
31. Systemic hemodynamics and regional blood flows during chronic nitric oxide synthesis inhibition in pregnancy
32. Effect of renal perfusion pressure on renal interstitial hydrostatic pressure and Na excretion: Role of endothelium-derived nitric oxide
33. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia
34. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation
35. Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats
36. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
37. Endothelins in the normal and diseased kidney
38. Endothelin: Potential role in hypertension and vascular hypertrophy
39. Endothelin antagonist improve renal function in spontaneously hypertensive rats
40. Cardiovascular and renal actions of endothelin receptor antagonism in Dahl salt-sensitive hypertension
41. Increased plasma levels of the novel vasoconstrictor peptide endothelin in severe pre-eclampsia
42. Plasma endothelin levels in preeclampsia: Elevation and correlation with uric acid levels and renal impairment
43. Preeclampsia: An endothelial cell disorder
44. Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies
45. Chronic hypertension produced by long-term pathophysiological increases in circulating endothelin levels in conscious dogs
46. Systemic hemodynamics and renal function during long-term pathophysiological increases in circulating endothelin
47. Endothelin-A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure
48. Placenta lipid peroxides and thromboxane are increased and prostacyclin is decreased in women with preeclampsia
49. Preeclampsia: A review of the role of prostaglandins
50. Renal synthesis and urinary excretion of eicosanoids during pregnancy in rats
51. The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood
52. Importance of prostaglandins in hypertension during reduced uteroplacental perfusion pressure
53. Thromboxane synthesis and action within the kidney
54. Overview of physiological and pathophysiological effects of thromboxane A2
55. Enhanced production of thromboxane A2 in response to chronic reductions in uterine perfusion pressure in pregnant rats
56. Role of sodium and fluid excretion in hypertension
57. Role of the renin-angiotensin system in hypertension during reduced uteroplacental perfusion pressure
58. Role of the renin-angiotensin system in mediating the hypertension produced by chronic reductions in uterine perfusion pressure in the pregnant rat
59. Placental cytokines and the pathogenesis of preeclampsia
60. Cytokines and endothelial cell biology
61. Transcriptional regulation of the endothelin-1 gene by TNFα
62. Tumor necrosis factor-alpha I is elevated in plasma and amniotic fluid of patients with severe preeclampsia
63. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
64. A new animal model for human preeclampsia: Ultra-low-dose endotoxin infusion in pregnant rats
65. Long-term elevation of plasma TNF-alpha increases arterial pressure and reduces kidney function in pregnant rats
66. Chronic reductions in uterine perfusion pressure in the pregnant rat produces hypertension and reduces pressure-natriuresis