Controversies on the sensitivity of the diabetic heart to ischemic injury: The sensitivity of the diabetic heart to ischemic injury is decreased

Cardiovascular Research

Volumn 34, Issue 1, 1997, Pages 113-120

  Feuvray, Danielle ^a   Lopaschuk, Gary D ^b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Diabetes; intracellular; Myocardial ischemia; Na+ H+ exchange; pH

Indexed keywords

FATTY ACID; GLUCOSE; LACTIC ACID; PROTON;

CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PH; DIABETES MELLITUS; ENERGY METABOLISM; FATTY ACID BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; PRIORITY JOURNAL; PROTON TRANSPORT; REPERFUSION INJURY; REVIEW;

ANIMALS; CALCIUM; CARDIOMYOPATHIES; DIABETES COMPLICATIONS; DIABETES MELLITUS; GLUCOSE; GLYCOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; SODIUM-HYDROGEN ANTIPORTER;

EID: 0030909702     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00037-0     Document Type: Review

References (84)

1. Bradley RF, Bryfogle JW. Survival of diabetic patients after myocardial infarction. Am J Med 1956;30:207-216.
2. Kesler I. Mortality experience of diabetic patients: a twenty-six year follow-up study. Am J Med 1971;51:715-724.
3. Partamian JO, Bradley JW. Acute myocardial infarction in 258 cases of diabetes. Immediate mortality and five-year survival. N Engl J Med 1965;273:455-461.
4. Rytter L, Troelsen S, Beck-Nielsen H. Prevalence and mortality of acute myocardial infarction in patients with diabetes. Diabetes Care 1985;8:230-234.
5. Ulvenstam G, Aberg A, Bergstrand R, et al. Long-term prognosis after myocardial infarction in men with diabetes. Diabetes 1985;34:787-792
6. Fein FS, Kornstein LB, Strobeck JE, Capasso JM, Sonnenblick EH. Altered myocardial mechanics in diabetic rats. Circ Res 1980;47:922-933.
7. Mustonen JN, Uusitupa MU, Tahvanainen K, et al. Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease. Am J Cardiol 1988;62:1273-1279.
8. Ledet T. Diabetic cardiomyopathy: quantitative histological studies of the heart from young juvenile diabetics. Acta Pathol Microbiol Scand 1976;84:421-428.
9. Shirey EK, Proudfit WL, Hawk WA. Primary myocardial disease. Correlation with clinical findings, angiographic and biopsy diagnosis. Follow-up of 139 patients. Am Heart J 1980;99:198-207.
10. Kannel WB, McGee DL. Diabetes and cardiovascular risk factors: the Framingham study. Circulation 1979;59:8-13.
11. Gwilt DJ, Petri M, Lewis PW, Nattrass M, Pentecost BL. Myocardial infarct size and mortality in diabetic patients. Br Heart J 1985;54:466-472.
12. Jaffe AS, Spadaro JJ, Schechtman K, Roberts R, Geltman EM, Sobel BE. Increased congestive heart failure after myocardial infarction of modest extent in patients with diabetes mellitus. Am Heart J 1984;108:31-37.
13. Stone PH, Muller JE, Hartwel T, et al. The effect of diabetes mellitus on prognosis and serial left ventricular function after acute myocardial infarction: Contribution of both coronary disease and diastolic left ventricular dysfunction to the adverse prognosis. J Am Coll Cardiol 1989;14:49-57.
14. Gotzsche O. Myocardial cell dysfunction in diabetes mellitus. Diabetes 1986;35:1158-1162.
15. Harrower AD, Clarke BF. Experience of coronary care in diabetics. Br Med J 1976;a:126-128.
16. Kannel BW, McGee DL. Diabetes and cardiovascular disease. The Framingham Study. J Am Med Assoc 1979;241:2035-2038.
17. Tahiliani AG, McNeill JH. Diabetes-induced abnormalities in the myocardium. Life Sci 1986;38:959-974.
18. Lopaschuk GD. Alterations in myocardial fatty acid metabolism contribute to ischemic injury in the diabetic. Can J Cardiol 1989;5:315-320.
19. Oswald B, Corcovan S, Yudkin JS. Prevalence and risks of hyperglycemia and undiagnosed diabetes in patients with acute myocardial infarction. Lancet 1984;1:1264-1267.
20. Haider B, Ahmed SS, Moschos CB, Oldewurtel HA, Regan TJ. Myocardial function and coronary blood flow response to acute ischemia in chronic canine diabetes. Circ Res 1977;40:577-583.
21. Liu Y, Thornton JD, Cohen MV, Downey JM, Schaffer SW.Streptozotocin-induced non-insulin-dependent diabetes protects the heart frominfarction. Circulation 1993;88:1273-1278.
22. Ingebretsen CG, Moreau P, Hawelu-Johnson C, Ingebretsen WR Jr. Performance of diabetic rat hearts: Effects of anoxia and increased work. Am J Physiol 1980;239:H614-H620.
23. Hearse DJ, Stewart DA, Chain EB. Diabetes and the survival and recovery of the anoxic myocardium. J Mol Cell Cardiol 1975;7:397-415.
24. Mokuda O, Sakamoto Y, Ikeda T, Mashiba H. Effects of anoxia and low free fatty acid on myocardial energy metabolism in streptozotocin-diabetic rats. Ann Nutr Metab 1990;34:259-265.
25. Savabi F, Kirsch A. Altered functional activity and anoxic tolerance in diabetic rat isolated aorta. Arch Biochem Biophys 1990;279:183-187.
26. Feuvray D, Idell-Wenger JA, Neely JR. Effects of ischemia on rat myocardial function and metabolism in diabetes. Circ Res 1979;44:322-329.
27. Lopaschuk GD, Spafford M. Response of isolated working hearts from acutely and chronically diabetic rats to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow. Circ Res 1989;65:378-387.
28. Lopaschuk GD, Spafford M. Acute insulin withdrawal contributes to ischemic heart failure in spontaneously diabetic BB Wistar rats. Can J Physiol Pharmacol 1990;68:462-466.
29. Broderick TL, Barr RL, Quinney HA, Lopaschuk GD. Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia. Metabolism 1992;41:332-338.
30. Lopaschuk GD, Belke DB, Gamble J, Itoi T, Schönekess BO. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta 1994;1213:263-276.
31. Lopaschuk GD, Spafford MA. Glucose and palmitate oxidation during reperfusion, of ischemic hearts from diabetic rats. Diabet Heart 1991;1:451-464.
32. Pieper GM. Superoxide dismutase plus catalase improves postischemic recovery in the diabetic heart. Cardiovasc Res 1988;22:916-926.
33. Vogel WM, Apstein CS. Effects of alloxan-induced diabetes on ischemic reperfusion injury in rabbit hearts. Circ Res 1988;62;975-982.
34. Hekimian G, Feuvray D. Reduction of ischemia-induced acyl carnitine accumulation by TDGA and its influence on lactate dehydrogenase release in diabetic rat hearts. Diabetes 1986;35:906-910.
35. 2+ metabolism. Circ Res 1988;62:931-940.
36. Lopaschuk GD, Saddik M, Barr R, Huang L, Barker CC, Muzyka RA. Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats. Am J Physiol 1992;263:E1046-E1053.
37. Broderick TL, Quinney HA, Lopaschuk GD. L-Carnitine increase glucose metabolism and mechanical function following ischemia in diabetic rat heart. Cardiovasc Res 1995;29:373-378.
38. Paulson DJ, Kopp SJ, Peace DG, Tow JP. Improved post-ischemic recovery of cardiac pump function in exercised trained diabetic rats. J Appl Physiol 1988;65:187-193.
39. Pieper GM, Gross GJ. Diabetes alters postischemic response to a prostacyclin mimetic. Am J Physiol 1989;256:H1353-H1360.
40. Randle PJ. α-Ketoglutarate dehydrogenase complexes and respiratory fuel utilization in diabetes. Diabetologia 1985;28:479-484.
41. Randle PJ, Hales CN, Garland PB, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetic mellitus. Lancet 1963;1:785-789.
42. Neely JR, Morgan HE. Relationship between carbohydrate metabolism and energy balance of heart muscle. Annu Rev Physiol 1974;36:413-459.
43. French, TJ, Goode AW, Holness MJ, MacLennan, PA, Sugden MC. The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state. Biochem J 1988;256:935-939.
44. Opie LH. Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction - Relation to myocardial ischemia and infarct size. Am J Cardiol 1975;36:938-953.
45. Neely JR, Grotyohann LW. Role of glycolytic products in damage to ischemic myocardium. Circ Res 1984;55:816-824.
46. Garland PB, Randle PJ. Regulation of glucose uptake by muscle. X. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy and of fatty acids, ketone bodies and pyruvate on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl coenzyme A, glycerol phosphate and citrate cycle intermediates in rat hearts and diaphragm muscles. Biochem J 1970;93:678.
47. Wall SR, Lopaschuk GD. Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats. Biochim Biophys Acta 1989;1006:97-103.
48. Cross HR, Opie LH, Radda GK, Clarke K. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? Circ Res 1996;78:482-491.
49. Higuchi M, Miyagi K, Nakasone J, Sakanashi M. Role of high glycogen in underperfused diabetic rat hearts with added epinephrine. J Cardiovasc Pharmacol 1995;26:899-907.
50. Saddik M, Lopaschuk GD. Myocardial triglyceride turnover and contribution to energy substrate utilization in isolated working rat hearts. J Biol Chem 1991;266:8162-8170.
51. Allison SP, Chamberlain MJ, Hinton P. Intravenous glucose tolerance, insulin, glucose and free fatty acid levels after myocardial infarction. Br Med J 1969;4:776-778.
52. Mueller HS, Ayres ST. Metabolic responses of the heart in acute myocardial infarction in man. Am J Cardiol 1978;42:363-371.
53. Oliver MR, Kurien VA, Greenwood TW. Relation between serum-free-fatty acid and arrhythmia and death after myocardial infarction. Lancet 1968;1:710-715.
54. Lopaschuk GD, Collins-Nakai R, Olley PM, et al. Plasma fatty acid levels in infants and adults after myocardial ischemia. Am Heart J 1994;128:61-67.
55. Marban E, Koretsune Y, Corretti M, Chacko VP, Kusuoka H. Calcium and its role in myocardial cell injury during ischemia and reperfusion. Circulation 1989;80:IV-17-IV-22.
56. Steenbergen C, Murphy E, Watts JA, London RE. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ Res 1990;66:135-146.
57. Reimer KA, Jennings RB. Myocardial ischemia, hypoxia and infarction. In: HA Fozzard, E Haber, RB Jennings, AM Katz, HE Morgan, eds. The Heart and Cardiovascular System. New York: Raven Press, 1986;1133-1201.
58. Fralix TA, Murphy TA, London RE, Steenbergen C. Protective effects of adenosine in the perfused rat heart: changes in metabolism and intracellular ion homeostasis. Am J Physiol 1993;264:C986-C994.
59. i in perfused hearts. Circ Res 1990;66:1255-1267.
60. 2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 1990;22:57-72.
61. 2+ overload in reperfused ischemic myocardium. Annu Rev Physiol 1990;52:543-559.
62. 2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ Res 1989;65:1045-1056.
63. 2+ exchange in hypoxic, ischemic, and reperfused rat hearts. Am J Physiol 1984;247:H239-H243.
64. Feher JJ, LeBolt WR, Manson NH. Differential effects of global ischemia on the ryanodine-sensitive and ryanodine-insensitive calcium uptake of cardiac sarcoplasmic reticulum. Circ Res 1989;65:1400-1408.
65. Lopaschuk GD. Abnormal mechanical function in diabetes:relationship to altered myocardial carbohydrate/lipid metabolism. Coronary Artery Dis 1996;7:116-123.
66. Roos A, Boron WE. Intracellular pH. Physiol Rev 1981;61:296-434.
67. Vaughan-Jones RD. Regulation of intracellular pH in cardiac muscle. In: Proton Passage across Cell Membranes. Ciba Foundation Symposium, 1988;139:23-46.
68. Feuvray D. Response of ischemia and reperfusion by the diabetic heart. In: Karmazyn M, ed. Myocardial Ischemia: Mechanisms, Reperfusion, Protection. Basel: Birkhäuser Verlag, 1996;409-421.
69. + exchange during ischemia and reperfusion of normal and diabetic rat hearts. Cardiovasc Res 1990;24:873-878.
70. Randle PJ, Newsholme EA, Garland PB. Regulation of glucose uptake by muscle. Effects of fatty acid, ketone bodies and pyruvate, and of alloxan diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscle. Biochem J 1964;93:652-665.
71. Wolfe CL, Gilbert HF, Brindle KM, Radda GK. Determination of buffering capacity of rat myocardium during ischemia. Biochim Biophys Acta 1988;971:9-20.
72. + exchange in diabetic rat isolated ventricular myocytes. Circ Res 1997;80;253-260.
73. Neely JR, Whitmer JT, Rovetto MJ. Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts. Circ Res 1975;36:733-741.
74. Vanheel B, de Hemptinne A, Leusen I. Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle. Am J Physiol 1986;250:C748-C760.
75. + exchange in the sheep cardiac Purkinje fibre. J Physiol (Lond) 1990;428:441-466.
76. i recovery from intracellular acidosis in the guinea-pig ventricular myocyte. J Physiol (Lond) 1992;458:361-384.
77. + symport activity in diabetic ventricular myocytes. J Mol Cell Cardiol 1996;28:A67.
78. Poole RC, Halestrap AP. Transport of lactate and othermonocarboxylates across mammalian plasma membranes. Am J Physiol 1993;264:C761-C782.
79. Wang X, Levi AJ, Halestrap AP. Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pHi. Am J Physiol 1994;267:H1759-H1769.
80. Khandoudi N, Bernard M, Cozzone P, Feuvray D. Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts. Diabetes 1995;44:196-202.
81. Lagadic-Gossmann D, Chesnais JM, Feuvray D. Intracellular pH regulation in papillary muscle from streptozotocin diabetic rats: an ion-sensitive microelectrode study. Pflügers Arch 1988;414:613-617.
82. + exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. Am J Physiol 1990;258:H255-H261.
83. Meng H-P, Pierce GN. Protective effects of 5-(N,N-dimethyl) amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 1990;258:H1615-H1619.
84. Moffat MP, Karmazyn M. Protective effect of the potent Na/H exchange inhibitor methyl-isobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea pig hearts. J Mol Cell Cardiol 1993;25:959-971.