Different sensitivities to competitive inhibition of benzodiazepine receptor binding of11C-iomazenil and11C-flumazenil in rhesus monkey brain

Annals of Nuclear Medicine

Volumn 15, Issue 2, 2001, Pages 137-139

  Inoue, Osamu ^a   Hosoi, Rie ^a   Kobayashi, Kaoru ^a   Itoh, Takashi ^b   Gee, Antony ^c   Suzuki, Kazutoshi ^d  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

11C flumazenil; 11C iomazenil; Benzodiazepine receptors; PET; Rhesus monkey

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; FLUMAZENIL; IOMAZENIL; TRACER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN CORTEX; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; IMAGE ANALYSIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RECEPTOR BINDING; RHESUS MONKEY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CARBON RADIOISOTOPES; FLUMAZENIL; KINETICS; MACACA MULATTA; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, GABA-A; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0034986602     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02988604     Document Type: Article

References (8)

1. 125l-iomazenil in intact mouse brain
2. 11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: Suppression of its radiolysis
3. 11C]methylspiperone binding in vivo: Positron emission tomography study using conscious rhesus monkey
4. 11C]-labelled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography
5. 3H]QNB binding by proton-beam irradiation in intact rat brain: An apparent positive cooperativity of binding
6. Changes in apparent rates of receptor binding in the intact brain in relation to the heterogeneity of reaction environments
7. Blood-brain barrier transport and protein binding of flumazenil and iomazenil in the rat: Implications for neuroreceptor studies
8. 2 receptor binding in vivo