Alterations of cell cycle regulators affecting the RB pathway in nonfamilial retinoblastoma

Human Pathology

Volumn 32, Issue 5, 2001, Pages 537-544

  Orjuela, Manuela ^a,b,c,d,e   Orlow, Irene ^a,b,c,d,e   Dudas, Maria ^a,b,c,d,e   Ponce Castaeda, M Veronica ^a,b,c,d,e   Ridaura, Cecilia ^a,b,c,d,e   Leal, Carlos ^a,b,c,d,e   Salazar, Antonio ^a,b,c,d,e   Abramson, David ^a,b,c,d,e   Gerald, William ^a,b,c,d,e   Cordon Cardo, Carlos ^a,b,c,d,e  

^a Howard Hughes Medical Institute   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^d INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

^e Department of Molecular Biology and Genetics   (United States)

Author keywords

E2F; Immunohistochemistry; P16; Retinoblastoma

Indexed keywords

KI 67 ANTIGEN; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; CANCER STAGING; CELL CYCLE; CHILD; COHORT ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA;

EID: 0034982173     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.24325     Document Type: Article

References (33)

1. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
2. Human retinoblastoma susceptibility gene: Cloning, identification, and sequence
3. Mutation and cancer: Statistical study of retinoblastoma
4. Mortality from second tumors among long-term survivors of retinoblastoma
5. Control of pRB phosphorylation
6. Sequences in EIA proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen
7. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
8. E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest
9. The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif
10. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
11. Growth suppression by p16 requires functional retinoblastoma protein
12. Results of a stage-based protocol for the treatment of retinoblastoma
13. Etoposide and carboplatin in extraocular retinoblastoma: A study by the Societe Francaise d'Oncologie Pediatrique
14. Optic nerve involvement in retinoblastoma
15. Age and lateness of referral as determinants of extraocular retinoblastoma
16. Late diagnosis of retinoblastoma in a developing country
17. The use of bone marrow aspirations and lumbar punctures at the time of diagnosis of retinoblastoma
18. Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas
19. Deletion of the p16 and p15 genes in human bladder tumors
20. Alterations of the INK4A and INK4B genes in adult soft tissue sarcomas: Effect on survival
21. Germline p16 mutations in familial melanoma
22. Cooperative effects of INK4a and Ras in melanoma susceptibility in vivo
23. Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53
24. Unilateral versus bilateral retinoblastoma. Correlations between age at diagnosis and stage of ocular disease
25. Adverse clinical outcome in Hodgkin's disease is associated with loss of retinoblastoma protein expression, high Ki67 proliferation index, and absence of Epstein-Barr virus-latent membrane protein 1 expression
26. Retinoblastoma protein expression and MIB-1 correlate with survival of patients with malignant astrocytoma
27. Expression of retinoblastoma gene product and p21 (WAF1/Cip1) protein in gliomas: Correlations with proliferation markers, p53 expression and survival
28. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines
29. Mutations and altered expression of p16INK4 in human cancer
30. Increased p16 levels correlate with pRb alterations in human urothelial cells
31. Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas
32. Expression of p16 induces transcriptional downregulation of the RB gene
33. Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells