Skeletal growth acceleration with growth hormone secretagogues in transgenic growth retarded rats: Pattern-dependent effects and mechanisms of desensitization

Journal of Neuroendocrinology

Volumn 13, Issue 6, 2001, Pages 496-504

  Wells, T ^a   Houston, P A ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Growth hormone; Growth hormone secretagogue receptors; Growth hormone secretagogues; Skeletal growth; Transgenic rats

Indexed keywords

CORTICOSTERONE; GROWTH HORMONE DERIVATIVE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR[1-29]; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MESSENGER RNA; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BOLUS INJECTION; BONE GROWTH; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DOWN REGULATION; DRUG INFUSION; DWARFISM; FEMALE; GENETIC MODEL; GROWTH ACCELERATION; GROWTH HORMONE DEFICIENCY; GROWTH RATE; HORMONE INHIBITION; HORMONE RESPONSE; HYPOPHYSIS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSATILE DRUG RELEASE; RAT; TRANSGENIC ANIMAL; WEIGHT GAIN;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ARCUATE NUCLEUS; BONE DEVELOPMENT; CORTICOSTERONE; FEMALE; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HORMONES; KINETICS; MALE; NEUROPEPTIDE Y; OLIGOPEPTIDES; PEPTIDE HORMONES; PEPTIDES; PITUITARY GLAND; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SOMATOSTATIN;

EID: 0034980320     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00661.x     Document Type: Article

References (53)

1. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
2. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
3. Identification of a new G-protein-linked receptor for growth hormone secretagogues
4. A receptor in pituitary and hypothalamus that functions in growth hormone release
5. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors
6. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
7. Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat
8. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6
9. Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurones
10. Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep
11. Design and biological activities of L-163,191 (MK-0677): A potent orally active growth hormone secretagogue
12. GH-deficient dw/dw rats and lit/lit mice show increased fos expression in the hypothalamic arcuate nucleus following systemic injection of GH-releasing peptide-6
13. Growth hormone (GH) secretion in the dwarf rat: Release, clearance and responsiveness to GH-releasing factor and somatostatin
14. The effects of growth hormone secretagogues on prolactin release in anaesthetized dwarf (dw/dw) rats
15. A new dwarf rat: Dominant negative phenotype in GRF-GH transgenic growth retarded (Tgr) rats
16. Effects of GH secretagogues in the transgenic growth retarded (Tgr) rat
17. Ghrelin induces adiposity in rodents
18. Intracerebroventricular growth hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats
19. 2 stimulate growth hormone release through distinct receptor sites
20. 2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat pituitary cell culture
21. Cumulative effects of patterned i.v. infusions of GHRP-6 and GRF in transgenic growth retarded (Tgr) rats
22. Pattern dependent effects of GHRP-6 infusions on the hypothalamo-pituitary axis and skeletal growth in transgenic growth retarded rats
23. The tibia test for growth hormone
24. Some histological methods. Trichrome stainings and their preliminary technique
25. Hypothalamic growth hormone receptor gene expression in the rat: Effects of altered growth hormone status
26. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats
27. The effects of a growth hormone-releasing peptide and growth hormone-releasing factor in conscious and anaesthetized rats
28. Receptor-associated resistance to growth hormone-releasing factor in dwarf 'little' mice
29. Growth hormone-deficient dwarfism in the rat: A new mutation
30. Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats
31. Intravenous growth hormone: Growth responses to patterned infusions in hypophysectomized rats
32. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
33. Consistent responses to repeated injections of GH-releasing hexapeptide (GHRP-6) and the non-peptide GH secretagogue, L-692,585
34. Growth hormone secretagogues: Characterization, efficacy and minimal bioactive conformation
35. Glucocorticoid regulation of growth hormone (GH) secretagogue-induced growth responses and GH secretagogue receptor expression in the rat
36. Growth-hormone (GH) secretion during continuous infusion of GH-releasing peptide-partial response attenuation
37. Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat
38. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression
39. Growth hormone-releasing factor binding sites in rat anterior pituitary membrane homogenates: Modulation by glucocorticoids
40. Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF)
41. Glucocorticoid treatment or food-deprivation counteract the stimulating effect of growth-hormone on rat cortical bone strength
42. Effects of repeated doses and continuous infusions of the growth hormone-releasing peptide hexarelin in conscious male rats
43. A novel peptidyl growth hormone secretagogue
44. In vitro characterization of four novel classes of growth hormone-releasing peptide
45. Growth hormone-releasing peptide (GHRP-6) regulation of hypothalamic gene expression
46. Growth hormone responses and ghrelin expression in growth hormone secretagogue receptor (GHS-R) transgenic mice
47. Chronic central infusion of growth hormone secretagogues: Effects on fos expression and peptide gene expression in the rat arcuate nucleus
48. Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture
49. Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles
50. Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK0677, on a 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men
51. The effect of chronic hexarelin administration on the pituitary-adrenal axis and prolactin
52. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-1 levels in beagles
53. Growth hormone releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone