Genetic association studies of schizophrenia using the 8p21-22 genes: Prepronociceptin (PNOC), neuronal nicotinic cholinergic receptor alpha polypeptide 2 (CNRNA2) and arylamine N-acetyltransferase 1 (NAT1)

European Journal of Human Genetics

Volumn 9, Issue 6, 2001, Pages 469-472

  Blaveri, Ekaterini ^a   Kalsi, Gursharan ^a   Lawrence, Jacob ^a,b,c   Quested, Digby ^d   Moorey, Helen ^b,c   Lamb, Graham ^b,c   Kohen, Dora ^b   Shiwach, Raj ^c   Chowdhury, Utom ^b,c   Curtis, David ^e   McQuillin, Andrew ^a   Gramoustianou, Eva S ^a   Gurling, Hugh M D ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b CAMDEN AND ISLINGTON NHS FOUNDATION TRUST   (United Kingdom)

^c SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^d WARNEFORD HOSPITAL   (United Kingdom)

^e ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Candidate gene; D8S2611; Neuronal acetylcholine receptor; Neuropeptides; Polymorphism; Schizophrenia

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; NICOTINIC RECEPTOR ALPHA POLYPEPTIDE 2; NUCLEIC ACID BASE; NUCLEOTIDE; POLYPEPTIDE; PREPRONOCICEPTIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; BRAIN; CASE CONTROL STUDY; CHROMOSOME 8P; CHROMOSOME MAP; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FAMILY; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MARKER GENE; POPULATION; PREVALENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SAMPLE; SCHIZOPHRENIA;

EID: 0034978141     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200646     Document Type: Article

References (19)

1. Linkage of familial schizophrenia to chromosome 13q32
2. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
3. Genome-wide linkage analysis confirms the presence of susceptibility loci for schizophrenia on chromosomes 1q32.2, 5q33.2 and 8p21-22 and provides support for linkage to schizophrenia on chromosomes 11q23.3-24 and 20q12.1-11.23
4. Orphanin FQ/nociceptin: A role in pain and analgesia, but so much more
5. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
6. Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA
7. Mapping AAC1, AAC2 and AACP, the genes for arylamin N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours
8. A polydiagnostic application of operational criteria in studies of psychotic illness - Development and reliability of the opcrit system
9. Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer
10. Genotyping human arylamine N-acetyltransferase type 1 (NAT1): The identification of two novel allelic variants
11. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci
12. Linkage disequilibrium between alleles at marker loci
13. Construction of Bacterial Artificial Chromosome libraries using the modified P1 (PAC) system
14. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene
15. Association studies in psychiatric genetics
16. Candidate genes in psychiatry: An epidemiological perspective
17. Association vs linkage analysis in mental disorders