Mutations on fibrinogen (γ316-322) are associated with reduction in platelet adhesion under flow conditions

Annals of the New York Academy of Sciences

Volumn 936, Issue , 2001, Pages 444-448

  Remijn, Jasper A ^a   Lounes, Karim C ^b   Hogan, Kelly A ^b   Lord, Susan T ^b   Galanakis, Dennis K ^c   Sixma, Jan J ^a   De Groot, Philip G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Fibrinogen chain; Flow conditions; Platelet adhesion

Indexed keywords

AMINO ACID; FIBRINOGEN;

AMINO ACID SUBSTITUTION; BLOOD FLOW; CONFERENCE PAPER; DYSFIBRINOGENEMIA; GENE DELETION; HUMAN; MUTATION; SHEAR RATE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION;

EID: 0034977042     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03528.x     Document Type: Conference Paper

References (11)

1. Exposure of platelet fibrinogen receptors by ADP and epinephrine
2. Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation
3. Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets
4. Adhesive properties of the beta 3 integrins: Comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells
5. Evidence that fibrin alpha-chain RGDX sequences are not required for platelet adhesion in flowing whole blood
6. Role of fibrinogen alpha and gamma chain sites in platelet aggregation
7. Binding of recombinant fibrinogen mutants to platelets
8. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3
9. Adhesion of platelets to surface-bound fibrinogen under flow
10. Fibrin(ogen) peptide B beta 15-42 inhibits platelet aggregation and fibrinogen binding to activated platelets
11. A new perfusion chamber to detect platelet adhesion using a small volume of blood