Effect of imidazo[1,2-a]pyrimidine derivatives on leukocyte function

Inflammation Research

Volumn 50, Issue 6, 2001, Pages 317-320

  Vidal, A ^a   Ferrandiz M L ^a   Ubeda, A ^a   Acero Alarcon A ^a   Sepulveda Arques, J ^a   Alcaraz, M J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Degranulation; Imidazo 1,2 a pyrimidines; Leukocyte; Mouse air pouch; Superoxide

Indexed keywords

ELASTASE; IMIDAZO[1,2 A]PYRIMIDINE DERIVATIVE; LEUKOTRIENE B4; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PROSTAGLANDIN E2; SUPEROXIDE; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DEGRANULATION; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE FUNCTION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE;

EID: 0034975709     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000250     Document Type: Article

References (23)

1. Neutrophils, host defense, and inflammation: A double-edged sword
2. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients
3. Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis
4. Peroxynitrite: A putative cytotoxin
5. Nitric oxide: Cytotoxicity versus cytoprotection- How, why, when and where?
6. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
7. Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite, and carbon dioxide
8. Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives
9. Research on heterocyclic compounds. Antiinflammatory activity of some imidazo(1,2-c)pyrimidine derivatives
10. Inhibition of constitutive and inducible nitric oxide synthase: Potential selective inhibition
11. Unusual ring closure reaction of amides with pyrimidines: Novel steroselective synthesis of hexahydroimidazo[1,2-c]pyrimidines
12. A study of the novel anti-inflammatory agent florifenine. Topical antiinflammatory activity and influence on arachidonic acid metabolism and neutrophil functions
13. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
14. 4 and tumour necrosis factor α release in acute inflammatory responses by novel prenylated hydroquinone derivatives
15. Detecting oxy radicals by chemiluminescence
16. Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids
17. A fluorometric assay for the measurement of nitrite in biological samples
18. Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages
19. Effects of non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte functions in vitro: Focus on fenamates
20. Antirheumatic agents and leukocyte recruitment. New light on the mechanism of action of oxaceprol
21. Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages
22. Modulation of granuloma formation by endogenous nitric oxide
23. A nitric oxide synthase inhibitor reduces inflammation, down- regulates inflammatory cytokines and enhances interleukin-10 production in carrageenin-induced oedema in mice