A conserved sequence block in the murine and human T cell receptor Jα loci interacts with developmentally regulated nucleoprotein complexes in vitro and associates with GATA-3 and Octamer-binding factors in vivo

European Journal of Immunology

Volumn 31, Issue 6, 2001, Pages 1696-1705

  Chen, Mei Ling ^a   Kuo, Chia Lam ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Chromatin accessibility; Conserved sequence block; T cell development; Transcription factor; V(D)J recombination

Indexed keywords

CIS ACTING ELEMENT; NUCLEOPROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; RECOMBINASE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CELL MATURATION; CHROMATIN; CHROMATIN STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FETUS; GENE LOCUS; HUMAN; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR UPREGULATION; THYMOCYTE; THYMUS; TISSUE SPECIFICITY;

ANIMALS; BRAIN; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GATA3 TRANSCRIPTION FACTOR; HOST CELL FACTOR C1; HUMANS; IMMUNOGLOBULIN JOINING REGION; LIVER; MICE; NUCLEOPROTEINS; OCTAMER TRANSCRIPTION FACTOR-1; OCTAMER TRANSCRIPTION FACTOR-2; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; THYMUS GLAND; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034974446     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200106)31:6<1696::AID-IMMU1696>3.0.CO;2-N     Document Type: Article

References (40)

1. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition
2. The structure, function, and molecular genetics of the gamma/delta T cell receptor
3. V(D)J recombination: Molecular biology and regulation
4. Potential targets for autosomal SCID mutations
5. Transcriptional regulation of T cell receptor genes
6. Temporal and lineage-specific control of the T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers
7. Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
8. A conserved sequence block in murine and human T cell receptor (TCR) Jα region is a composite element that enhances TCR α enhancer activity and binds multiple nuclear factors
9. Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor C alpha/C delta region
10. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: Organization, sequence, and evolution of 97.6 kb of DNA
11. Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA
12. Regulation of the human T-cell receptor alpha gene enhancer: Multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements
13. The T alpha 2 nuclear protein binding site from the human T cell receptor alpha enhancer functions as both a T cell-specific transcriptional activator and repressor
14. A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus
15. Nonrandom use of Jα gene segments influence of Vα and Jα gene location
16. Restricted onset of T cell receptor α gene rearrangement in fetal and neonatal thymocytes
17. First T cell receptor α gene rearrangements during T cell ontogeny skew to the 5 ́region of the Jα locus
18. Evidence for recombinatorial hot spots at the T cell receptor Jα locus
19. Function of the TCR α enhancer in αβ and γδ T cells
20. A developmental switch from TCR δ enhancer to TCR α enhancer function during thymocyte maturation
21. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells
22. Formaldehyde cross-linking and immunoprecipitation demonstrate developmental changes in H1 association with transcriptionally active genes
23. CREB regulates MHC class II expression in a CIITA-dependent manner
24. A role for histone acetylation in the developmental regulation of V(D)J recombination
25. Human GATA-3: A lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene
26. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family
27. The human enhancer-binding protein Gata3 bind to several T-cell receptor regulatory element
28. Transcription factor GATA-3 is required for development of the T-cell lineage
29. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
30. CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites
31. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation
32. + T cells express perturbed AP-1 and NF-Kappa B transcription factors
33. Induction of the POU domain transcription factor Oct-2 during T-cell activation by coganate antigen
34. Gene transcription in differentiating immature T cell receptor (neg) thymocytes resembles antigen-activated mature T cells
35. Deletional rearrangement in the human T-cell receptor α-chain locus
36. Functional characterization of the promoter for the human germ-line T cell receptor J alpha (TEA) transcript
37. Defect in rearrangement of the most 5 ́TCR-Jα following targeted deletion of T early α (TEA): Implications for TCR α locus accessibility
38. A conserved sequence block in the murine and human TCR Jα region: Assessment of regulatory function in vivo
39. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
40. DNA binding and meiotic chromosomal localization of the Drosophila Nod kinesin-like protein