Affinity, complementarity, cooperativity, and specificity in antibody recognition

Current Topics in Microbiology and Immunology

Volumn 260, Issue , 2001, Pages 65-85

  Greenspan, N S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; COOPERATION; MOLECULAR INTERACTION; MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; THERMODYNAMICS;

EID: 0034972112     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-662-05783-4_5     Document Type: Review

References (66)

1. The role of antibody concentration and avidity in antiviral protection
2. Bound water molecules and conformational stabilization help mediate an antigen-antibody association
3. Structure of the streptococcal groups A, A-variant, and C carbohydrates
4. H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate
5. Variable domain-identical antibodies exhibit IgG subclass-related differences in affinity and kinetic constants as determined by surface plasmon resonance
6. Role of heavy chain constant domains in antibody-antigen interaction: Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains
7. The influence of polyvalency on the binding properties of antibodies
8. Altered specificity of DNA-binding proteins with transition metal dimerization domains
9. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis
10. Interactions of protein antigens with antibodies
11. The function of individual zinc fingers in sequence-specific DNA recognition by transcription factor IIIA
12. Site-specific analysis of mutational effects in proteins
13. Site-specific thermodynamics: Understanding cooperativity in molecular recognition
14. Mixing two monoclonal antibodies yields enhanced affinity for antigen
15. A relation between the principal axes of inertia and ligand binding
16. Cooperativity: Over the hill
17. The propagation of binding interactions to remote sites in proteins: Analysis of the binding of the monoclonal antibody D1.3 to lysozyme
18. Antibody affinity. VII. Multivalent interaction of anti-lactoside antibody
19. Epitopes, paratopes, and other topes: Do immunologists know what they are talking about?
20. Conceptions of epitopes and paratopes and the ontological dynamics of immunological recognition
21. Dimensions of antigen recognition and levels of immunological specificity
22. Cooperative binding by mouse IgG3 antibodies: Implications for functional affinity, effector function, and isotype restriction
23. Complementarity, specificity, and the nature of epitopes and paratopes in multivalent interactions
24. Defining epitopes: It's not as easy at it seems
25. Fc region-dependence of IgG3 anti-streptococcal group A carbohydrate antibody functional affinity. I. The effect of temperature
26. Interaction of IgG3 anti-streptococcal group A carbohydrate (GAC) antibody with streptococcal group A vaccine: Enhancing and inhibiting effects of anti-GAC, anti-isotypic, and anti-idiotypic antibodies
27. The contribution of contact and non-contact residues of antibody in the affinity of binding to antigen: The interaction of mutant D1.3 antibodies with lysozyme
28. Antibody-induced conformational changes result in enhanced avidity of antibodies to different antigenic sites on the tick-borne encephalitis virus glycoprotein
29. Enhancement of monoclonal antibodies against HLA-A2 is due to antibody bivalency
30. Nonstatistical binding of a protein to clustered carbohydrates
31. Antibody affinity III. The role of multivalence
32. Receptor binding redefined by a structural switch in a mutant human insulin
33. On the attribution and additivity of binding energies
34. Principles of protein-protein interactions
35. Multivalent binding and functional affinity
36. The affinity of antibody: Range, variability, and the role of multivalence
37. Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme
38. Shape complementarity at protein/protein interfaces
39. Antibody-mediated clearance of alphavirus infection from neurons
40. Water: Now you see it, now you don't
41. Alternative packing arrangements in the hydrophobic core of lambda repressor
42. Electrostatic complementarity at protein/protein interfaces
43. Transmembrane signaling: The joy of aggregation
44. Confinement as a determinant of macromolecular structure
45. Macromolecular crowding and molecular recognition
46. Quantitative explanation for increased affinity shown by mixtures of monoclonal antibodies: Importance of a circular complex
47. 2a) allotypic determinants detected with monoclonal antibodies
48. Tetravalent miniantibodies with high avidity assembling in Escherichia coli
49. Further studies on the epitopes of HLA-B7 defined by murine monoclonal antibodies
50. Molecular structure and intermolecular forces
51. The nature of the intermolecular forces operative in biological processes
52. Substrate specificity and affinity of a protein modulated by bound water molecules
53. Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen
54. Structural evidence for induced fit as a mechanism for antibody-antigen recognition
55. The biological significance of antibody affinity
56. Cyclic complexes and high avidity antibodies
57. Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface
58. Cytologic assessment of nuclear and cytoplasmic O-linked N-acetyl-glucosamine distribution by using anti-streptococcal monoclonal antibodies
59. Role of immunoglobulin valency and heavy chain constant domain in antibody-mediated downregulation of Sindbis virus replication in persistently infected neurons
60. Avidity as a determinant of the protective efficacy of human antibodies to pneumococcal capsular polysaccharides
61. Energetics of ligand binding to proteins
62. Antibody-antigen interactions
63. Aspects of weak interactions
64. Antibody-antigen interactions: New structures and new conformational changes
65. Macromolecular crowding: Biochemical, biophysical, and physiological consequences