Metabolism of norethisterone and norethisterone derivatives in rat uterus, vagina, and aorta

Drug Metabolism and Disposition

Volumn 29, Issue 7, 2001, Pages 976-982

  Blom, M J ^a,c   Groot Wassink, M ^a   Van Wijk, F ^a   Ederveen, A G H ^b   Kloosterboer, H J ^b   Verhoeven, C H J ^b   Lambert, J G D ^a   Goos, H J Th ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

^c Xendo Laboratories BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA ETHYL NORETHISTERONE; 20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXY 5ALPHA H NORETHISTERONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 7ALPHA METHYL 11 ETHYLIDENE NORETHISTERONE; 7ALPHA METHYL NORETHISTERONE; DRUG METABOLITE; NORETHISTERONE; NORETHISTERONE DERIVATIVE; ORG 34694; ORG 4060; ORG OM 38; STEROID 5ALPHA REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTRACEPTION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; HORMONE SUBSTITUTION; ISOTOPE LABELING; NONHUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; RAT; TISSUE METABOLISM; UTERUS; VAGINA;

ANIMALS; AORTA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FEMALE; NORETHINDRONE; PROGESTERONE; RATS; RATS, WISTAR; UTERUS; VAGINA;

ANIMALIA;

EID: 0034962645     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

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2. Variable expression of the uteroglobin gene following the administration of norethisterone and its A-ring reduced metabolites
3. The effect of estrogen dose on postmenopausal bone loss
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6. Conservation of function between mammalian and plant steroid 5alpha-reductases
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8. The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening
9. Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites
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