Site-directed mutagenesis studies of the NADPH-binding domain of rat steroid 5α-reductase (isozyme-1) I: Analysis of aromatic and hydroxylated amino acid residues

Steroids

Volumn 64, Issue 5, 1999, Pages 356-362

  Wang, M ^a   Bhattacharyya, A K ^a   Taylor, M F ^a   Tai, H H ^a   Collins, D C ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cofactor; Mutagenesis; Site directed

Indexed keywords

ISOENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 5ALPHA REDUCTASE;

AMINO ACID ANALYSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; ENZYME INACTIVATION; HYDROXYLATION; MEMBRANE BINDING; PROTEIN DOMAIN; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; COS CELLS; HYDROXYLATION; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NADP; POINT MUTATION; RATS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0033021395     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(99)00010-0     Document Type: Article

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