Cell death in the colorectal cancer cell line HT29 in response to glucosinolate metabolites

Journal of the Science of Food and Agriculture

Volumn 81, Issue 9, 2001, Pages 959-961

  Lund, Elizabeth K ^a   Smith, Tracy K ^a   Clarke, Rosemary G ^a   Johnson, Ian T ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Adherence; Apoptosis; Free radical; G2 M; Isothiocyanate

Indexed keywords

ANALYTICAL PROCEDURES AND TECHNIQUES; APOPTOSIS; CARCINOMA CELL; CASPASE; CELL ADHESION; CELL DEATH; CELL GROWTH; CELL LINE; DNA DETERMINATION; ENZYME INHIBITION; GLUCOSINOLATE; GROWTH INHIBITION; ISOTHIOCYANIC ACID DERIVATIVE; PROTEIN P53; SIGNAL TRANSDUCTION; SULFORAPHANE;

EID: 0034958523     PISSN: 00225142     EISSN: None     Source Type: Journal    
DOI: 10.1002/jsfa.904     Document Type: Conference Paper

References (12)

1. Epidemiological studies on brassica vegetables and cancer risk
2. Inhibition of dimethylhy-drazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin
3. Apoptosis can be detected in attached colonic adenocarcinoma HT29 cells using annexin V binding, but not by other flow cytometric techniques
4. Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase
5. Disruption of epithelial cell-matrix interactions induces apoptosis
6. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
7. Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro
8. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
9. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes
10. Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates
11. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
12. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoli