The apparent lipophilicity of quaternary ammonium ions is influenced by galvani potential difference, not ion-pairing: A cyclic voltammetry study

Pharmaceutical Research

Volumn 18, Issue 5, 2001, Pages 702-708

  Bouchard, Géraldine ^a   Carrupt, Pierre Alain ^a   Testa, Bernard ^a   Gobry, Véronique ^b   Girault, Hubert H ^b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

Author keywords

Cyclic voltammetry; Ion pairing; ITIES; Lipophilicity; Quaternary ammonium ions

Indexed keywords

1,2 DICHLOROETHANE; ELECTROLYTE; QUATERNARY AMMONIUM DERIVATIVE; WATER;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CYCLIC POTENTIOMETRY; LIPOPHILICITY; PARTITION COEFFICIENT; PRIORITY JOURNAL; SIMULATION; TITRIMETRY;

CHEMISTRY, PHYSICAL; ELECTROCHEMISTRY; ETHYLENE DICHLORIDES; INDICATORS AND REAGENTS; LIPIDS; QUATERNARY AMMONIUM COMPOUNDS; WATER;

EID: 0034957416     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011001914685     Document Type: Article

References (30)

1. Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds
2. Formation of ion-pairs in aqueous solutions of diclofenac salts
3. Enhanced in vitro percutaneous penetration of salicylate by ion pair formation with alkylamines
4. The dermal delivery of lignocaine: Influence of ion pairing
5. Ion pair skin transport of a zwitterionic drug, cephalexin
6. Hydrophobic ion pairing: Altering the solubility properties of biomolecules
7. Quantitative evaluation of aqueous isopropanol enhancement of skin flux of terbutaline (sulfate). I. Ion associations and species equilibria in the formulation
8. The aqueous solution behavior of large univalent ions. New type of ion-pairing
9. Ion pair transport across membranes
10. The ion-pair concept: Its evolution and some applications
11. Ion pair absorption of ionized drugs-fact or fiction?
12. Cyclic voltammetry as a new tool to study the partitioning and proton transport behavior of ionized drugs
13. Electrochemical properties of the interface between two immiscible electrolyte solutions. Part I. Equilibrium situation and Galvani potential difference
14. Limiting behavior in equilibrium partitioning of ionic components in liquid-liquid two-phase systems
15. 1,2-Dichloroethane (Environmental Health Criteria No 176)
16. Mechanism of transfer of a basic drug across the water/1,2-dichloroethane interface: The case of quinidine
17. Galvani potential scales for water-nitrobenzene and water-1,2-dichloroethane interfaces
18. Relative scale of free energy of transfer of anions from water to 1,2-dichloroethane
19. Ion-pair of quaternary ammonium drugs: The influence of counter ions of different lipophilicity, size, and flexibility
20. Calculation of ionic solvation. V. The calculation of partition coefficients of ions
21. Charge and delocalisation effects on the lipophilicity of protonable drugs
22. Non-bornian theory of the Gibbs energy of ion transfer between two immiscible liquids
23. Intermolecular forces expressed in 1,2-dichloroethane/water partition coefficient: A solvatochromic analysis
24. An electrochemical study of long-chain aliphatic amines
25. Ion pairing in the analysis of voltammetric data at the ITIES: RbTPB and RbTPBCl in 1,2-dichloroethane
26. Standard Gibbs energies of transfer of univalent ions from water to 1,2-dichloroethane
27. Determination of the half-wave potential of the species limiting the potential window: Measurement of Gibbs transfer energies at the water/1,2-dichloroethane interface
28. Ionic partition of ionisable drugs: pH-lipophilicity profiles, transfer mechanisms and charge effects on solvation
29. Assessment of distribution-pH profiles