Helper T-lymphocyte precursor frequency predicts the occurrence of graft-versus-host disease and disease relapse after allogeneic bone marrow transplantation from HLA-identical siblings

Haematologica

Volumn 86, Issue 6, 2001, Pages 652-656

  Leung, A Y H ^a   Kwok, J ^a   Lie, A K W ^a   Chen, P ^a   Chen, F E ^a   Liang, R ^a  

^a QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Graft versus host disease; Helper T cell precursor frequency; Relapse

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 2; METHOTREXATE;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; DISEASE SEVERITY; FEMALE; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HELPER CELL; HLA SYSTEM; HUMAN; MALE; OUTCOMES RESEARCH; PREDICTION; PROLYMPHOCYTE; RELAPSE; RISK ASSESSMENT; SIBLING;

ADOLESCENT; ADULT; BLOOD DONORS; BONE MARROW TRANSPLANTATION; COHORT STUDIES; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY TESTING; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECURRENCE; T-LYMPHOCYTES, HELPER-INDUCER; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 0034955843     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Progress in bone marrow transplantation for leukaemia: A preliminary report from the Advisory Committee of the International Bone Marrow Transplant Registry
2. Graft failure and leukemia relapse following T lymphocyte-depleted bone marrow transplants: Effects of intensification of immunosuppressive conditioning
3. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias
4. Donor helper T-cell frequencies as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings
5. Host-specific interleukin-2-secreting donor T-cell precursors as predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings
6. Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation
7. Predictive value of host-specific donor helper T-cell precursor frequency for acute graft-versus-host disease and relapse in HLA-identical siblings receiving allogeneic bone marrow transplantation for hematological malignancies
8. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors
9. The evaluation of limiting dilution assays
10. Helper and cytotoxic T cell precursor frequencies are not predictive for development of acute graft-versus-host disease after partially T cell-depleted HLA-identical sibling BMT
11. The pathophysiology of acute graft-versus-host disease in a murine transplant model
12. HLA-DPB1 mismatch at position 69 is associated with high helper T lymphocyte precursor frequencies in unrelated bone marrow transplant pairs
13. In vitro separation of specific graft-versus-host and graft-versus-leukaemia cytotoxic T cell activities