Drug discovery and target validation

Cells Tissues Organs

Volumn 169, Issue 3, 2001, Pages 265-271

  Nuttall, Mark E ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Drug discovery; Genomics; Pharmaceuticals; Proteomics

Indexed keywords

ANABOLIC AGENT; ANTIRHEUMATIC AGENT; CASPASE INHIBITOR;

CONFERENCE PAPER; DRUG TARGETING; GENE EXPRESSION; HUMAN; OSTEOARTHRITIS; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TEMPOROMANDIBULAR JOINT DISORDER;

ANIMALS; BONE RESORPTION; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENOMICS; HUMANS; PROTEOME; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPOROMANDIBULAR JOINT DISORDERS;

EID: 0034954744     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000047890     Document Type: Conference Paper

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2. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
3. Genetic control of programmed cell death in the nematode C. elegans
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5. Applications of combinatorial technologies to drug discovery: Combinatorial organic synthesis, library screening strategies and future directions
6. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis
7. Apoptosis in human osteoarthritic cartilage: A microscopy report
8. The new genomics: Global views of biology
9. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
10. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips: Correlation of morphology and metabolic data
11. Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro
12. Proteomics to study genes and genomes
13. Transcript imaging of the development of human T helper cells using oligonucleotide arrays
14. Differential cloning of growth hormone-regulated hepatic transcripts in the aged rat
15. Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage