Lack of insulin inhibition on insulin secretion in non-diabetic morbidly obese patients

International Journal of Obesity

Volumn 25, Issue 6, 2001, Pages 798-804

  Muscelli, E ^a   Pereira, J A ^a   Lazarin, M A C T ^a   Da Silva, C A ^a   Pareja, J C ^a   Saad, M J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

C peptide; Insulin clamp; Insulin resistance; Insulin secretion; Obesity

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; BODY MASS; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE TOLERANCE TEST; HUMAN; HYPERINSULINEMIA; IMPEDANCE; INHIBITION KINETICS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; MALE; MORBID OBESITY; PATHOGENESIS; PEPTIDE ANALYSIS; PRIORITY JOURNAL;

EID: 0034950978     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801607     Document Type: Article

References (46)

1. Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men
2. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men
3. A prospective study of obesity and risk of coronary heart disease in women
4. Variability of body weight and health outcomes in the Framingham population
5. Insulin action and resistance in obesity and non insulin-dependent type 1 diabetes mellitus
6. Obesity and insulin resistance in humans: A dose-response study
7. Metabolic and cardiovascular assessment in moderate obesity: Effect of weight loss
8. Correlation between insulin clearance and insulin responsiveness: Studies in normal, obese, hyperthyroid and Cushing's syndrome patients
9. Quantitative study of insulin secretion and clearance in normal and obese subjects
10. 1983 Hyperinsulinemia of obesity is due to decreased clearance of insulin
11. Peripheral hyperinsulinemia of simple obesity: Pancreatic hypersecretion or impaired insulin metabolism
12. Twenty-four hour profiles and pulsatile pattern of insulin secretion in normal and obese subjects
13. β-Cell hypersecretion and not reduced hepatic insulin extraction is the main cause of hyperinsulinemia in obese nondiabetic subjects
14. Insulin resistance and hypersecretion in obesity
15. Inhibition of insulin secretion by exogenous insulin in normal man as demonstrated by C-peptide assay
16. Failure of insulin of infusion during euglycemia to influence endogenous basal insulin secretion
17. Lack of insulin feedback inhibition in non-obese and obese men
18. Insulin resistance in Graves' disease: A quantitative in-vivo evaluation
19. Feedback inhibition of insulin and glucagon secretion by insulin is altered in abdominal obesity with normal or impaired glucose tolerance
20. Feedback inhibition of insulin secretion in type 2 diabetes
21. Failure of human insulin to influence endogenous basal insulin secretion in mild diabetics
22. Tissue-specific knockout of the insulin receptor in pancreatic β-cells creates an insulin secretory defect similar to that in type 2 diabetes
23. Feedback inhibition of insulin secretion by insulin: Relation to the hyperinsulinemia of obesity
24. Effects of morbid obesity on insulin clearance and insulin sensitivity in several aspects of metabolism as assessed by low-dose insulin infusion
25. The fifth report of the joint national committee on detection, evaluation, and treatment of high blood pressure (JNC V)
26. National Diabetes Data Group classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
27. A comparison of measurements of lean body mass derived by bioelectrical impedance, skinfold thickness and total body potassium. A study in obese and non-obese normal subjects
28. Glucose clamp technique: A method for quantifying insulin secretion and resistance
29. Effects of arterial versus venous sampling on analysis of glucose kinetics in man
30. The kinetics of insulin in man. General aspects
31. On the linearity of insulin kinetics
32. Metabolism of C-peptide in dogs: In vivo demonstration of the absence of hepatic extraction
33. Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia
34. The pancreatic glucagon and C-peptide secretion during hyperinsulinemia in euglycemic glucose clamp with or without somatostatin infusion in normal man
35. Suppression of basal, but not glucose stimulated secretion by human insulin in healthy and obese hyperinsulinemic subjects
36. Normal inhibition by somatostatin of glucose-stimulated β-cell secretion in obese subjects
37. Effect of low dose somatostatin infusion on pancreatic and gastric function in lean and obese non diabetic human subjects
38. Evidence that suppression of insulin secretion by insulin itself is neurally mediated
39. Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas
40. Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans
41. Autonomic and hemodynamic responses to insulin in lean and obese humans
42. Body fat and sympathetic nerve activity in healthy subjects
43. Sympathetic activation in obese normotensive subjects
44. Glucose and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
45. Glucose induced receptor tyrosine phosphorylation in insulin-secretion beta-cells
46. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects