Apamin-sensitive nitric oxide- and ATP-mediated motor effects on the guinea pig small intestine

General Physiology and Biophysics

Volumn 20, Issue 1, 2001, Pages 97-108

  Ivancheva, Ch ^a   Rahamimoff, R ^b   Radomirov, Radomir ^a  

^a INSTITUTE OF PHYSIOLOGY   (Bulgaria)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Apamin; ATP; Ileum motor activity; Nitric oxide

Indexed keywords

ADENOSINE TRIPHOSPHATE; APAMIN; ARGININE; CALCIUM; NITRIC OXIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PURINE P2 RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; ELECTROSTIMULATION; GUINEA PIG; ILEUM; INTESTINE MOTILITY; MALE; MOTOR ACTIVITY; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TONE; MUSCLE TWITCH; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN;

ADENOSINE TRIPHOSPHATE; ANIMALS; APAMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; GUINEA PIGS; ILEUM; INTESTINE, SMALL; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROARGININE; NITROPRUSSIDE;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034950380     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bauer V., Kuriyama H. (1982): Evidence for non-cholinergic non-adrenergic transmission in the guinea pig ileum. J. Physiol. (London) 330, 95-110
2. Bauer V. (1993): NANC transmission in intestines and its pharmacological modulation. Acta Neurobiol. Exp. 53, 65-77
3. Bolotina V. M., Najibi S., Palacino J. J., Pagano P. J., Cohen R. A. (1994): Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 368, 850-853
4. Bult H., Boeckxtaens G. E., Pelckmans P. P., Jordaens F. H., Van Maercke Y. M., Herman A. G. (1990): Nitric oxide as inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 345, 346-347
5. Costa M., Furness J. B., Humphreys C. M. (1986): Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea pig gastrointestinal tract. Naunyn-Schmiedeberg's Arch. Pharmacol. 332, 79-88
6. Fernandez E., Guo X., Vergara P., Jimenez M. (1998): Evidence supporting a role for ATP as non-adrenergic non-cholinergic inhibitory transmitter in the porcine ileum. Life Sci. 62, 1303-1315
7. Ivancheva Chr., Radomirov R. (1996): Met-enkephalin-dependent nitrergically mediated relaxation in the guinea pig ileum. Methods Find. Exp. Clin. Pharmacol. 18, 521-525
8. Ivancheva Chr., Pencheva N., Radomirov R. (1997): Pattern of non-adrenergic, non-cholinergic responses during short- or long-lasting electrical stimulation in guinea pig ileum. Gen. Pharmacol. 29, 233-237
9. Ivancheva Chr., Itzev D., Lolova I., Radomirov R. (1998): Contribution of nitric oxide and Substance P to nonadrenergic noncholinergic transmission in the guinea pig ileum. Gen. Pharmacol. 31, 101-105
10. Ivancheva Chr., Itzev D., Radomirov R. (2000): Functional antagonism between nitric oxide and ATP in the motor responses of guinea pig small intestine. J. Auton. Pharmacol. 20, 147-156
11. Johnson C. R., Charlton S. J., Hourani S. M. (1996): Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides. Br. J. Pharmacol. 117, 823-830
12. Kanada A., Hata F., Suthamnatpong N., Maehara T., Ishii T., Takeuchi T., Yagasaki O. (1992): Key roles of nitric oxide and cyclic GMP in nonadrenergic and noncholinergic inhibition in rat ileum. Eur. J. Pharmacol. 216, 287-292
13. Kennedy I., Humphrey P. P. (1994): Evidence for the presence of two types of P2 purinoceptor in the guinea pig ileal longitudinal smooth muscle preparation. Eur. J. Pharmacol. 261, 273-280
14. Lee S., Park M., So I., Earn Y. E. (1994): NADH and NAD modulates calcium-activated potassium channels in small pulmonary arterial smooth muscle cells of the rabbit. Pfluegers Arch. 427, 378-380
15. Lefebvre R. A., De Beurme F. A., Sas S. (1991): Effect of apamin on the responses to VIP, ATP and NANC neurone stimulation in the rat and cat gastric fundus. J. Auton. Pharmacol. 11, 73-83
16. Maas A. J., Den Hertog A. (1979): The effect of apamin on the smooth muscle cells of the guinea pig taenia coli. Eur. J. Pharmacol. 58, 151-156
17. Maggi C. A., Giuliani S. (1993): Multiple inhibitory mechanisms mediate non-adrenergic non-cholinergic relaxation in the circular muscle of the guinea pig colon. Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 630-634
18. Manzini S., Maggi C. A., Meli A. (1986): Pharmacological evidence that at least two different non-adrenergic non-cholinergic inhibitory systems are present in the rat small intestine. Eur. J. Pharmacol. 123, 229-236
19. Martins S. L., De Oliveira R. B., Ballejo G. (1995): Rat duodenum nitrergic-induced relaxations are cGMP-independent and apamin-sensitive. Eur. J. Pharmacol. 284, 265-270
20. Matsuyama H., Thapaliya S., Takewaki T. (1999): Cyclic GMP-associated apamin-sensitive nitrergic slow inhibitory junction potential in the hamster ileum. Br. J. Pharmacol. 128, 830-836
21. 1-purinoceptors on cholinergic nerve terminals in the guinea pig ileum. Eur. J. Pharmacol. 77, 1-9
22. Mule F., D'Angelo S., Serio R. (1999): Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels. Br. J. Pharmacol. 127, 514-520
23. Osthaus L. E., Galligan J. J. (1992): Antagonists of nitric oxide synthesis inhibit nerve mediated relaxations of longitudinal muscle in guinea pig ileum. J. Pharmacol. Exp. Ther. 260, 140-145
24. Rand M. J., Li C. G. (1995): Nitric oxide as a neurotransmitter in peripheral nerves. Annu. Rev. Physiol. 57, 659-682
25. Radomirov R., Venkova K. (1988): Pharmacological characteristics of the postsynaptically mediated contractile responses of guinea pig ileum to long-lasting electrical field stimulation. Neuropharmacology 27, 729-735
26. Serio R., Mule F., Postorino A., Vetri T., Bonvissuto F. (1996): Apamin-sensitive and - insensitive components of inhibitory junction potentials in rat caecum: role of nitric oxide. J. Auton. Pharmacol. 16, 183-189
27. Shuba M. F., Vladimirova I. A. (1980): Effect of apamin on the electrical responses of smooth muscle to adenosine 5'-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation. Neuroscience (Oxford) 5, 853-859
28. Shuttleworth C. W., Murphy R., Furness J. B. (1991): Evidence that nitric oxide participates in non-adrenergic inhibitory transmission to intestinal muscle in the guinea pig. Neurosci. Lett. 130, 77-80
29. Shuttleworth C. W., Sweeney K. M., Sanders K. M. (1999): Evidence that nitric oxide acts as an inhibitory neurotranstnitter supplying taenia from the guinea pig caecum. Br. J. Pharmacol. 127, 1495-1501
30. Tallarida R. J., Murray R. B. (1981): Manual of Pharmacologic Calculations with Computer Program. Springer-Verlag, New York, pp. 19-21
31. Tanobe Y., Fujiama M., Toda N. (1994): Nitric oxide as a putative non-adrenergic non-cholinergic neurotransmitter in dog duodenal muscle. Biomed. Res. 15, Suppl. 2, 183-185
32. Vladimirova I. A., Shuba M. F. (1978): The effect of strychnine, hydrastin and apamin on synaptic transmission in smooth muscle cells. Neirofiziologiia (Kiev) 10, 295-299 (in Russian)
33. Waldman S. A., Murad F. (1987): Cyclic GMP synthesis and function. Pharmacol. Rev. 39, 163-196
34. Watson M. J., Lang R. J., Bywater R. A., Taylor G. S. (1996): Characterization of the membrane conductance changes underlying the apamin-resistant NANC inhibitory junction potential in the guinea pig proximal and distal colon. J. Auton. Nerv. Syst. 60, 31-42
35. Williams S. J., Parsons M. E. (1995): Nitric oxide, an enteric nonadrenergic-noncholinergic relaxant transmitter. Evidence using phosphodiesterase V and nitric oxide synthase inhibition. Br. J. Pharmacol. 116, 1789-1796
36. Zagorodnyuk V., Maggi C. A. (1994): Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea pig colon. Br. J. Pharmacol. 112, 1077-1082
37. Zagorodnyuk V., Maggi C. A. (1998): Pharmacological evidence for the existence of multiple P2 receptors in the circular muscle of guinea pig colon. Br. J. Pharmacol. 123, 122-128
38. Zagorodnyuk V. P., Vladimirova I. A., Vovk E. V., Shuba M. F. (1989): Studies of the inhibitory non-adrenergic neuromuscular transmission in the smooth muscle of the normal human intestine and from a case of Hirschsprung's disease. J. Auton. Nerv. Syst. 26, 51-60