Synthesis and study of 5′-ester prodrugs of N6-cyclopentyladenosine, a selective A1 receptor agonist

Pharmaceutical Research

Volumn 18, Issue 4, 2001, Pages 531-536

  Dalpiaz, A ^a   Scatturin, A ^a   Menegatti, E ^a   Bortolotti, F ^a   Pavan, B ^a   Biondi, C ^a   Durini, E ^a   Manfredini, S ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Activity; Adenosine A1 receptor; Affinity; N6 cyclopentyladenosine; Prodrugs; Stability

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; PRODRUG;

ARTICLE; DEAMINATION; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; PRODRUGS; RATS; RECEPTORS, PURINERGIC P1;

EID: 0034949011     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011018730459     Document Type: Article

References (19)

1. Nomenclature and classification of purinoceptors
2. Novel therapeutics acting via purinergic receptors
3. Excitatory transmitter amino acid release form the ischemic rat cerebral cortex: Effects of adenosine receptor agonists and antagonists
4. + channels in cerebral ischemic preconditioning
5. Cloned receptors and cardiovascular responses to adenosine
6. 1 receptor agonist
7. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept?
8. Central versus peripheral mediation of responses to adenosine receotir agonists: Evidence against a central mode of action
9. Processing of adenosine receptor agonists in rat and human whole blood
10. 6-cyclopentyladenosine (CPA) in the rat
11. The effect of protecting groups of the nucleobase and the sugar mioeties on the acidic hydrolisis of the glycosidic bond of 2′-deoxyadenosine: A kinetic and NMR spectroscopic study
12. 1-selective agonists
13. Enzymatic synthesis of 2′-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil and of 2′-O-acyl-araU, -araC and -araA
14. 1 adenosine receptor cDNA
15. 1 adenosine receptor mediates specific agonistic binding
16. 1 receptors
17. Saturation assay for cyclic AMP using endogenous binding protein
18. Synthesis of nucleotide 5′-diphosphates from 5′-O-tosyl nucleosides