Analysis of soluble and cell surface factors regulating anti-DNA topoisomerase I autoantibody production demonstrates synergy between Th1 and Th2 autoreactive T cells

Journal of Immunology

Volumn 164, Issue 12, 2000, Pages 6138-6146

  Kuwana, Masataka ^a,d   Medsger Jr , Thomas A ^a,b   Wright, Timothy M ^a,b,c  

^a Division of Rheumatology and Clinical Immunology   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA TOPOISOMERASE;

ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CELL CULTURE; CELL INTERACTION; CYTOKINE PRODUCTION; HLA MATCHING; HUMAN; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; SYSTEMIC SCLEROSIS; T LYMPHOCYTE ACTIVATION;

EID: 0034659754     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.12.6138     Document Type: Article

References (55)

1. Medsger, T. A., Jr. 1993. Systemic sclerosis (scleroderma), localized forms of scleroderma, and calcinosis. In Arthritis and Allied Conditions, 12th Ed. D. J. McCarty and W. J. Koopman, eds. Lea & Febiger, Philadelphia, p. 1253.
2. Tan, E. M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44:93.
3. Wang, J. C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665.
4. Merino, A., K. R. Madden, W. S. Lane, J. J. Champoux, and D. Reinberg. 1993. DNA topoisomerase I is involved in both repression and activation of transcription. Nature 365:227.
5. Kretzschmar, M., M. Meisterernst, and R. G. Roeder. 1993. Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II. Proc. Natl. Acad. Sci USA 90:11508.
6. Shero, J. H., B. Bordwell, N. F. Rothfield, and W. C. Earnshaw. 1986. High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients. Science 231:737.
7. Kuwana, M., T. A. Medsger, Jr., and T. M. Wright. 1995. Detection of anti-DNA topoisomerase I antibody by an enzyme-linked immunosorbent assay using overlapping recombinant polypeptides. Clin. Immunol. Immunopathol. 76:266.
8. Kuwana, M., J. Kaburaki, T. Mimori, T. Tojo, and M. Homma. 1993. Autoantigenic epitopes on DNA topoisomerase I: clinical immunogenetic associations in systemic sclerosis. Arthritis Rheum. 36:1406.
9. Kuwana, M., J. Kaburaki, Y. Okano, H. Inoko, and K. Tsuji. 1993. The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma). J. Clin. Invest. 92:1296.
10. Reveille, J. D., E. Durban, M. J. MacLeod-St. Clair, R. Goldstein, R. Moreda, R. D. Altman, and F. C. Arnett. 1992. Association of amino acid sequences in the HLA-DQB1 first domain with the antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis). J. Clin. Invest. 90:973.
11. Morel, P. A., H. J. Chang, J. W. Wilson, C. Conte, S. L. Saidman, J. D. Bray, D. J. Tweardy, and T. A. Medsger, Jr. 1994. Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele. Hum. Immunol. 40:101.
12. Kuwana, M. T. A. Medsger, Jr., and T. M. Wright. 1995. T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors. J. Clin. Invest. 96:586.
13. Kuwana, M., T. A. Medsger, Jr., and T. M. Wright. 1995. T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis. J. Immunol. 155:2703.
14. Parker, D. C. 1993. T cell dependent B cell activation. Annu. Rev. Immunol. 11:331.
15. Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
16. Abbas, A. K., A. H. Lichtman, and J. S. Pober. 1994. Cellular and Molecular Immunology, 2nd Ed. Saunders, Philadelphia.
17. Lipsky, P. E. 1989. The control of antibody production by immunomodulatory molecules. Arthritis Rheum. 32:1345.
18. Kuwana, M., T. A. Medsger, Jr., and T. M. Wright. 1997. Highly restricted TCRαβ usage by autoreactive T cell clones specific for DNA topoisomerase I: recognition of an immunodominant epitope. J. Immunol. 158:485.
19. Inoko, H., and M. Ota. 1993. PCR-RFLP. In Handbook of HLA Typing Techniques. K. M Hui and J. L. Bidwell, eds. CRC Press, Boca Raton, p. 9.
20. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. 1980. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum. 23: 581.
21. Kuwana, M., J. Kaburaki, T. Mimori, T. Tojo, and M. Homma. 1993. Autoantibody reactive with three classes of the RNA polymerases in sera from patients with systemic sclerosis. J. Clin. Invest. 91:1399.
22. + T cells after activation with phorbol myristate acetate and phytohaemagglutinin. Clin. Exp. Immunol. 90:147.
23. Bouabula, M., P. Legoux, B. Pességué, B. Delpech, X. Dumont, M. Piechaczyk, P. Casellas, and D. Shire. 1992. Quantitation of cytokine gene expression using a polymerase chain reaction method involving co-amplification with an internal multispecific control. J. Biol. Chem. 267:21830.
24. Guba, S. C., C. I. Sartor, L. R. Gottschalk, J. Ye-Hu, T. Mulligan, and S. G. Emerson. 1992. Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte-macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by serum-free bioassay, enzyme-linked immunosorbent assay, and reverse transcriptase polymerase chain reaction. Blood 80: 1190.
25. Brenner, C. A., A. W. Tam, P. A. Nelson, E. G. Engleman, N. Suzuki, K. E. Fry, and J. W. Larrick. 1989. Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells. BioTechniques. 7:1096.
26. Xia, X., H.-K. Lee, S. C. Clark, and Y. S. Choi. 1989. Recombinant interleukin (IL) 2-induced human B cell differentiation is mediated by autocrine IL 6. Eur. J. Immunol. 19:2275.
27. Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167:332.
28. Parronchi, P., A. Tiri, D. Macchia, M. de Carli, P. Biswas, C. Simonelli, E. Maggi, G. del Prete, M. Ricci, and S. Romagnani. 1990. Noncognate contact-dependent B cell activation can promote IL-4-dependent in vitro human IgE synthesis. J. Immunol. 144:2102.
29. Smith, K. A. 1980. T-cell growth factor. Immunol. Rev. 51:335.
30. Nakagawa, N., T. Nakagawa, D. J. Volkman, J. L. Ambrus, Jr., and A. S. Fauci. 1987. The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system. J. Immunol. 138:795.
31. Jelinek, D. F., J. B. Splawski, and P. E. Lipsky. 1986. The role of interleukin 2 and interferon-γ in human B cell activation, growth and differentiation. Eur. J. Immunol. 16:825.
32. Shu, S., T. Chou, and S. A. Rosenberg. 1986. In vitro sensitization and expansion with viable tumor cells and interleukin 2 in the generation of specific therapeutic effector cells. J. Immunol. 136:3891.
33. Splawski, J. B., L. M. McAnally, and P. E. Lipsky. 1990. IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2). J. Immunol. 144:562.
34. Sakane, T., N. Suzuki, S. Takada, Y. Ueda, Y. Murakawa, T. Tsuchida, Y. Yamauchi, and T. Kishimoto. 1988. B cell hyperreactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 31:80.
35. Tanaka, Y., F. Shirakawa, T. Ota, H. Suzuki, S. Eto, and U. Yamashita. 1988. Mechanism of spontaneous activation of B cells in patients with systemic lupus erythematosus: analysis with anti-class II antibody. J. Immunol. 140:761.
36. Tanaka, Y., K. Saito, F. Shirakawa, T. Ota, H. Suzuki, S. Eto, and U. Yamashita. 1988. Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus. J. Immunol. 141:3043.
37. Kitani, A., M. Hara, T. Hirose, M. Harigai, K. Suzuki, M. Kawakami, Y. Kawaguchi, T. Hidaka, M. Kawagoe, and H. Nakamura. 1992. Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression. Clin. Exp. Immunol. 88:75.
38. Nagafuchi, H., N. Suzuki, Y. Mizushima, and T. Sakene. 1993. Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus. J. Immunol. 151:6525.
39. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Nature 254:279.
40. Katz, J. D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268:1185.
41. Coffman, R. L., B. W. Seymour, D. A. Lebman, D. D. Hiraki, J. A. Christiansen, B. Schrader, H. M. Cherwinski, H. F. J. Savelkoul, F. D. Finkelman, M. W. Bond, et al. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:5.
42. Kelso, A. 1995. Th1 and Th2 subsets: paradigms lost? Immunol. Today, 16:374.
43. + T cells. Annu. Rev. Immunol. 12:635.
44. Digherio, G., P. Lymberi, D. Holmberg, I. Lundquist, A. Coutinho, and S. Avrameas. 1983. High frequency of natural autoantibodies in normal newborn mice. J. Immunol. 134:765.
45. H sequence of a human anti-Sm autoantibody: evidence that autoantibodies can be unmutated copies of germline genes. J. Immunol. 142:883.
46. Vazques-Abad, D., V. Pascual, and N. F. Rothfield. 1993. Analysis of human antitopoisomerase-I idiotypes. J. Clin. Invest. 92:1302.
47. Moudgil, K. D., and E. E. Sercarz. 1994. The T cell repertoire against cryptic self determinants and its involvemenl in autoimmunity and cancer. Clin. Immunol. Immunopathol. 73:283.
48. Lanzavecchia, A. 1995. How can cryptic epitopes trigger autoimmunity. J. Exp. Med. 181:1945.
49. Lipham, W. J., T. M. Redmond, H. Takahashi, J. A. Berzofsky, B. Wiggert, G. J. Chander, and I. Grey. 1991. Recognition of peptides that are immunogenic but cryptic: mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune process. J. Immunol. 146:3757.
50. Dong, X., K. J. Hamilton, M. Satoh, J. Wang, and W. H. Reeves. 1994. Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J. Exp. Med. 179:1243.
51. Mann, K. 1993. Topoisomerase activity is associated with purified SV40 T antigen. Nucleic Acids Res. 21:1697.
52. Yamada, Y., N. Yamamoto, K. Maeno, and Y. Nishiyama. 1990. Role of DNA topoisomerase I in the replication of herpes simplex virus type 2. Arch. Virol. 110:121.
53. Ciavarra, R. P., C. Goldman, K.-K. Wen, B. Tadeschi, and F. J. Castora. 1994. Heat stress induces hsc70/nuclear topoisomerase I complex formation in vivo: evidence for hsc70-mediated ATP-independent reactivation in vitro. Proc. Natl. Acad Sci. USA 91:1751.
54. Casciola-Rosen, L. F., F. Wigley, and A. Rosen. 1997. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J. Exp. Med. 185:71.
55. Samuels, D. S., and N. Shimizu. 1994. The predominant form of mammalian DNA topoisomerase I in vivo has a molecular mass of 100 kDa. Mol. Biol. Rep. 19:99.