Substantia nigra pars reticulata is a highly potent site of action for the behavioral effects of the D1 antagonist SCH 23390 in the rat

Psychopharmacology

Volumn 156, Issue 1, 2001, Pages 32-41

  Trevitt, J T ^a   Carlson, B B ^a   Nowend, K ^a   Salamone, J D ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Basal ganglia; Dopamine; GABA; Motor; Neostriatum; Nucleus accumbens; Operant; Parkinson; Receptor

Indexed keywords

4 AMINOBUTYRIC ACID; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN CORTEX; BRAIN REGION; BRAIN STEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GABAERGIC SYSTEM; LOCOMOTION; MALE; NEOSTRIATUM; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RETICULAR FORMATION; SUBSTANTIA NIGRA;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; SUBSTANTIA NIGRA;

EID: 0034944774     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100708     Document Type: Article

References (89)

1. Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance
2. L-Dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats
3. D-1 receptor mediated modulation of the release of gamma-aminobutyric acid by endogenous dopamine in the basal ganglia of the rat
4. Combination of treatment of the partial D2 agonist terguride with the D1 agonist SKF 82958 in 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine-lesioned parkinsonian cynomolgus monkeys
5. Antistereotypic effects of dopamine D-1 and D-2 antagonists after intrastriatal injection in rats: Pharmacological and regional specificity
6. GABA in the ventral tegmental area: Differential regional effects on locomotion, aggression and food intake after microinjection of GABA agonists and antagonists
7. Effects of intraacumbens administration of SCH-23390 on cocaine-induced locomotion and conditioned place preference
8. Dopaminegric regulation of feeding behavior: I. Differential effects of haloperidol microinfusion into three striatal subregions
9. Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors
10. The role of dopamine in locomotor activity and learning
11. Effects of extinction, pimozide, SCH 23390 and metoclopramide on food-rewarded operant responding of rats
12. Microinjections of flupenthixol into the caudate putamen of rats produce intrasession declines in food-rewarded operant responding
13. Brain dopamine and the syndromes of Parkinson and Huntington: Clinical, morphological and neurochemical correlations
14. The substantia nigra as a site of synaptic integration of functionally diverse information arising from the ventral pallidum and the globus pallidus in the rat
15. 3H]SCH 23390, a selective D-1 antagonist ligand, in rat striatum
16. Intraaccumbens raclopride attenuates amphetamine-induced locomotion, but fails to prevent the response-reinstating properties of food reinforcement
17. Molecular diversity of the dopamine receptors
18. Changes in dopamine-mediated behaviour during one year's neuroleptic administration
19. The critical role of nucleus accumbens dopamine systems in the mediation of fixed interval schedule-controlled operant behavior
20. Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure
21. Involvement of ventrolateral striatal dopamine in movement initiation and execution: A microdialysis and behavioral investigation
22. Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat
23. Pharmacological characterization of performance on a concurrent lever pressing/feeding choice procedure: Effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs
24. The D1 dopamine receptor in the rat brain: Quantitative autoradiographic localization using an iodinated ligand
25. A simple cannula for intracerebral injections in chronic animals
26. The current clinical picture of Parkinson's disease
27. Substantia nigra
28. The cells of origin of nigrotectal, nigrothalamic and nigrostriatal projections in the rat
29. Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in rats
30. Involvement of pallidal and nigral GABA mechanisms in the generation of tremulous jaw movements in rats
31. The relative importance of dopamine and norepinephrine in mediating locomotor activity
32. Role of the substantia nigra in the expression of dopamine D1 receptor-mediated and D2 receptor-mediated behaviours
33. Activation of D1 receptors stimulates the release of GABA in the basal ganglia of the rat
34. Feedback loop or output pathway in striatonigral fibres?
35. The neostriatal mosaic: Multiple levels of organization in the basal ganglia
36. Basal ganglia
37. In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH23390
38. The D1 dopamine receptor antagonist, SCH 23390 reduces locomotor activity and rearing in rats
39. The role of mesoaccumbens-pallidal circuitry in novelty-induced behavioral activation
40. SCH 23390 - The first selective dopamine D-1 antagonist
41. SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems
42. Dopamine receptors and brain function
43. Role nigral dopamine in amphetamine-induced locomotor activity
44. Is it possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data?
45. Differential effects of mesocortical, mesolimbic, and mesostriatal dopamine depletion on spontaneous, conditioned, and drug-induced locomotor activity
46. Multiple dopamine receptors and behavior
47. Multiple dopamine receptors and their implications in medicine
48. Multiple receptors for dopamine
49. Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity
50. Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
51. Effects on locomotor activity after local application of (+)-UH232 in discrete areas of the rat brain
52. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat
53. Organization of the striatum: Collateralization of its efferent axons
54. Modulation of GABA release by dopamine in the substantia nigra
55. Tremulous jaw movements produced by acute tacrine administration: Possible relation to parkinsonian side effects
56. Striatal and nigral mechanisms involved in the antiparkinsonian effects of SKF 82958 (APB): Studies of tremulous jaw movements in rats
57. Enhancement of the acoustic startle response in rats by the dopamine D1 receptor agonist SKF 82958
58. Effects of intraccumbens dopamine agonist SK&F38393 and antagonist SCH23390 on locomotor activities in rats
59. Locomotor behaviors in response to new selective D-1 and D-2 dopamine receptor agonists, and the influence of selective antagonists
60. D1 or D2 antagonism in nucleus accumbens core or shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
61. Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D1 agonist C-APB in mice
62. Locomotor activation induced by MK-801 in the rat: Postsynaptic interactions with dopamine receptors in the ventral striatum
63. Functional anatomy of the basal ganglia I. The cortico-basal ganglia-thalamo-cortical loop
64. The striatopallidal and striatonigral projections: Two distinct fiber systems in primate
65. Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex
66. Behavioral pharmacology of dopamine systems: A new synthesis
67. Complex motor and sensorimotor functions of striatal and accumbens dopamine: Involvement in instrumental behavior processes
68. Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure
69. Ventrolateral striatal dopamine depletions impair feeding and food handling in rats
70. The role of brain dopamine in response initiation: Effects of haloperidol and regionally-specific dopamine depletions on the local rate of instrumental responding
71. Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis
72. Nucleus accumbens dopamine and rate of responding: Neurochemical and behavioral studies
73. Autoradiographic localization of D1 dopamine receptors in the rat brain with [3H]SCH 23390
74. The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurons
75. Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systemic amphetamine
76. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cAMP from rat neostriatum
77. Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys
78. Amphetamine-induced release of dendritic dopamine in substantia nigra pars reticulata: D1-mediated behavioral and electrophysiological effects
79. Effects of clozapine, thioridazine, risperidone and haloperidol on behavioral test related to extrapyramidal motor function
80. Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat
81. Behavioral assessment of atypical antipsychotics in rats: Studies of the effects of olanzapine (Zyprexa)
82. Interactions between dopamine D1 receptors and GABA mechanisms in substantia nigra pars reticulata: Neurochemical and behavioral studies
83. Differential effects of the selective D2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous and d-amphetamine-induced activity
84. [3H]SCH39166, a D1 dopamine receptor antagonist: Binding characteristics and localization
85. Neuroleptics and operant behavior: The anhedonia hypothesis
86. 2 dopamine receptors in responding with conditioned reinforcement
87. Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy
88. Intranigral injections of SCH 23390 inhibit SKF 82958-induced rotational behavior