Pharmacological profile of the mechanisms involved in the external carotid vascular effects of the antimigraine agent isometheptene in anaesthetised dogs

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 1, 2001, Pages 27-32

  Willems, E W ^a   Valdivia, L F ^a   Saxena, P R ^a   Villalon C M ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

5 HT1B 1D; Dog; External carotid bed; Imiloxan; Isometheptene; Migraine; Vasoconstriction; Adrenoceptor subtypes

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ANTIMIGRAINE AGENT; IMILOXAN; ISOMETHEPTENE; PENTOBARBITAL; PRAZOSIN; RAUWOLSCINE; RESERPINE; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTICLE; CAROTID ARTERY FLOW; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; EXTERNAL CAROTID ARTERY; HEART RATE; MEAN ARTERIAL PRESSURE; MIGRAINE; NONHUMAN; SYMPATHECTOMY; VAGOTOMY;

ANESTHESIA; ANIMALS; CAROTID ARTERY, EXTERNAL; DOGS; HEMODYNAMIC PROCESSES; METHYLAMINES; MIGRAINE DISORDERS; MODELS, ANIMAL; MOLECULAR STRUCTURE; PRAZOSIN; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; REGIONAL BLOOD FLOW; RESERPINE; SYMPATHECTOMY; SYMPATHOMIMETICS; VAGOTOMY; VASOCONSTRICTOR AGENTS;

EID: 0034944056     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100417     Document Type: Article

References (44)

1. 1F receptor agonists in human and bovine cerebral arteries: Similarity with human coronary artery
2. 2-adrenergic receptors
3. 1D receptor antagonist
4. 1B/D receptor ligand, with functional 5-HT receptors
5. 1D (BRL15572) receptor antagonists
6. 1B/1D and novel receptors
7. Pharmacological aspects of experimental headache models in relation to acute antimigraine therapy
8. 1D receptors in the sumatriptan-induced constriction of porcine carotid arteriovenous anastomoses
9. 3H]RX821002 binding and definition of additional selective drugs
10. Treatment of migraine with isometheptene, acetaminophen, and dichloralphenazone combination: A double-blind, crossover trial
11. Isometheptene - A non-ergot drug in the treatment of migraine
12. 2-adrenoceptors
13. 1c subtype
14. 1B receptors causes hypothermia in the guinea pig
15. Catecholamines, symapathomimetic drugs, and adrenergic receptor antagonists
16. 35S]GTPγS binding
17. Ventilation standards for small mammals
18. 2-adrenergic receptor subtype, the gene for which is located on chromosome 2
19. Reversible segmental cerebral arterial vasospasm and cerebral infarction: Possible association with excessive use of sumatriptan and Midrin
20. 2-adrenoceptor antagonists
21. 2-adrenoceptors
22. 1D receptors
23. Approach to the patient with migraine
24. Classification, mechanisms, and management of headache
25. A study of midrin in the symptomatic relief of migraine headache
26. The effects of antimigraine drugs on the vascular responses by 5-hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: Possible pharmacological implications to their antimigraine action
27. Cranial arteriovenous shunting, an in vivo animal model for migraine
28. 1B/1D receptor agonists in the acute treatment of migraine
29. 1-adrenergic receptors: Sequence corrections and direct comparison with other species homologues
30. 1-adrenoceptors and native tissues
31. The pharmacology of medications used in treating headache
32. Effect of isometheptene on the distribution and shunting of 15 μM microspheres throughout the cephalic circulation of the cat
33. 2C adrenoceptors
34. 1-adrenergic receptor subtypes in the regulation of arterial pressure
35. 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine
36. 1B receptor-mediated contractions in human temporal artery: Evidence from selective antagonists and 5-HT receptor mRNA expression
37. 1-like receptors in the increase in external carotid blood flow induced by 5-hydroxytryptamine in the dog
38. Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs
39. 2-adrenoceptors
40. 2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetised pigs
41. Pharmacological identification of the major subtypes of adrenoceptors involved in the external carotid vascular effects of adrenaline and noradrenaline in anaesthetised dogs
42. 2-adrenoceptor subtypes mediating vasoconstriction in the canine external carotid circulation
43. A study of a non-ergotamine agent in the office treatment of vascular headache