High glucose decreases matrix metalloproteinase-2 activity in rat mesangial cells via transforming growth factor-β1

Experimental Nephrology

Volumn 9, Issue 4, 2001, Pages 249-257

  Singh, Rekha ^a,b   Song, Ruo Hua ^a,b   Alavi, Nahid ^c   Pegoraro, Alfredo A ^d   Singh, Ashok K ^a,b,d   Leehey, David J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c JESSE BROWN VA MEDICAL CENTER   (United States)

^d Hektoen Institute for Medical Research   (United States)

Author keywords

Collagenase; Cytokine; Diabetes; Gelatinase A; Matrix

Indexed keywords

CYTOKINE ANTIBODY; FLUORESCEIN; GELATIN; GELATINASE A; GLUCOSE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANALYSIS; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; ZYMOGRAPHY;

ANIMALS; ANTIBODIES; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GLOMERULAR MESANGIUM; GLUCOSE; MALE; MATRIX METALLOPROTEINASE 2; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0034943382     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Phenotypic expression of collagen types in mesangial matrix of diabetic and nondiabetic rats
2. Early increased renal procollagen α1 (IV) mRNA levels in streptozotocin-induced diabetes
3. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium
4. Effect of high glucose on type IV collagen production by cultured glomerular epithelial, endothelial, and mesangial cells
5. Mechanisms of glucose-enhanced extracellular matrix accumulation in rat glomerular mesangial cells
6. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycemia
7. Decreased degradative enzymes in mesangial cells cultured in high glucose media
8. Effect of glucose and heparin on mesangial α-1 (IV) COLL and MMP-2/TIMP-2 mRNA expression
9. Identification and independent regulation of human mesangial cell metalloproteinases
10. Structural biochemistry and activation of matrix metalloproteinases
11. mRNA expression of growth factors in glomeruli from diabetic rats
12. Diabetic kidney disease is linked to elevated expression of transforming growth factor-β
13. 1 and fibronectin synthesis
14. 1 in mesangial cell culture by high glucose concentration
15. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β
16. 1 stimulates glomerular mesangial cell synthesis of the 72-kD type IV collagenase
17. 1
18. Transforming growth factor-β is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells
19. Role of plasmin and gelatinase in extracellular matrix degradation by cultured rat mesangial cells
20. The purification and characterization of a glomerular-basement-membrane-degrading neutral proteinase from rat mesangial cells
21. Homology cloning of rat 72 kDa collagenase: Cytokine and second-messenger inducibility in glomerular mesangial cells
22. 1 as a key mediator
23. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β
24. High glucose and TGF-β (1) stimulate fibronectin gene expression through a cAMP response element
25. Role for transforming growth factor-β in thromboxane-induced increases in mesangial cell fibronectin synthesis
26. 1 enhances glomerular collagen synthesis in diabetic rats
27. 2 in rat glomeruli
28. 1 gene expression in diabetic BB rat and NOD mouse
29. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
30. Transforming growth factor-β modulates the expression of collagenase and metalloproteinase inhibitors
31. ECM degradation by cultured human mesangial cells is mediated by a plasminogen activator/plasmin/MMP-2 cascade
32. Glomerular matrix accumulation is linked to inhibition of the plasmin protease system