Effect of pentoxifylline on nitrogen balance and 3-methylhistidine excretion in parenterally fed endotoxemic rats

Nutrition

Volumn 17, Issue 7-8, 2001, Pages 623-627

  Dickerson, Roland N ^a   Mouser, Jay F ^b   Methvin, J Travis ^a   Kuhl, David A ^a   Hak, Emily B ^a   Brown, Rex O ^a   Hak, Lawrence J ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Animal; Endotoxins; Lipopolysaccharides; Methylhistidine; Nitrogen balance; Parenteral nutrition; Pentoxifylline; Phosphodiesterase inhibitors; Rats; Sepsis; Xanthines

Indexed keywords

3 METHYLHISTIDINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 1; INTERLEUKIN 6; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; ENDOTOXEMIA; GENE ACTIVATION; MALE; NITROGEN BALANCE; NONHUMAN; PARENTERAL NUTRITION; PRIORITY JOURNAL; RAT; SEPSIS; SURVIVAL; URINARY EXCRETION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; LIPOPOLYSACCHARIDES; MALE; METHYLHISTIDINES; NITROGEN; PARENTERAL NUTRITION; PENTOXIFYLLINE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034943165     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(01)00554-8     Document Type: Article

References (52)

1. Changes in body balances of nitrogen and other key nutrients; description and underlying mechanisms
2. Amino acid and energy metabolism in septic and traumatized patients
3. Parenteral nutrition in septic patients; effect of increasing nitrogen intake
4. Comparison of glucose, LCT, and LCT plus MCT as calorie sources for parenterally nourished septic rats
5. Use of selected visceral protein measurements in the comparison of branched-chain amino acids with standard amino acids in parenteral nutrition support of injured patients
6. Pentobarbital improves nitrogen retention in sepsis
7. Effect of propranolol on nitrogen and energy metabolism in sepsis
8. The effect of insulin-like growth factor-1 on protein metabolism and hepatic response to endotoxemia in parenterally fed rats
9. The effect of alpha-adrenergic antagonism upon nitrogen loss during endotoxemia
10. Dose-dependent effect of octreotide on nitrogen retention and glucose homeostasis in response to endotoxemia in parenterally fed rats
11. Metabolic intervention in surgical patients; the effect of alpha- or beta-blockade on glucose and protein metabolism in surgical patients receiving total parenteral nutrition
12. Metabolic intervention in surgical patients. An assessment of the effect of somatostatin, ranitidine, naloxone, diclophenac, dipyridamole, or salbutamol infusion on energy and protein kinetics in surgical patients using stable and radioisotopes
13. Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline
14. Pentoxifylline-induced modulation of human leukocyte function in vitro
15. Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats
16. Effect of pentoxifylline on survival and intestinal cytokine messenger RNA transcription in a rat model of ongoing peritoneal sepsis
17. Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1
18. Tumor necrosis factor induces skeletal muscle protein breakdown in rats
19. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins
20. Growth and body composition during long-term total parenteral nutrition in the rat
21. Effect of sustained endotoxemia on alpha1-adrenergic responsiveness in parenterally fed rats
22. Alterations in N-acetylation of 3-methylhistidine in endotoxemic parenterally fed rats
23. Insulin-like growth factor 1 and endotoxin-mediated kidney dysfunction in critically ill, parenterally fed rats
24. Octreotide and potassium homeostasis
25. The effects of endotoxaemia on protein metabolism in skeletal muscle and liver of fed and fasted rats
26. The effects of pentoxifylline on bacterial peritonitis
27. Pentoxifylline in the treatment of experimental peritonitis in rats
28. Pentoxifylline decreases body weight loss and muscle protein wasting characteristics of sepsis
29. Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response during sepsis
30. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats
31. Nitrogen estimation in biological samples by use of chemiluminescence
32. Methods for assessing nutritional status of patients with renal failure
33. Standardization of acid hydrolysis procedure for urinary 3-methylhistidine determination by high-performance liquid chromatography
34. Sequential changes in the metabolic response in severely septic patients during the first 23 days after the onset of peritonitis
35. Whole body protein kinetics in severely septic patients. The response to glucose infusion and total parenteral nutrition
36. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients
37. Both inflammatory and endocrine mediators stimulate host responses to sepsis
38. Pentoxifylline improves insulin action limiting skeletal muscle catabolism after infection
39. Mechanism of the beneficial effects of pentoxifylline during sepsis; maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines
40. Effects of pentoxifylline on hemodynamics and oxygenation in septic and nonseptic patients
41. Effect of pentoxifylline in severe sepsis; results of a randomized, double-blind, placebo-controlled study
42. Pentoxifylline preserves small-intestine microvascular blood flow during bacteremia
43. Pentoxifylline improves tissue oxygenation after hemorrhagic shock
44. Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality
45. A quantitative evaluation of stress associated with indwelling superior vena cava cannulae in rats
46. Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis
47. Pentoxifylline restores intestinal microvascular blood flow during resuscitated hemorrhagic shock
48. Pentoxifylline but not saralasin restores hepatic blood flow after resuscitation from hemorrhagic shock
49. Pentoxifylline prevention of altered hepatocyte calcium regulation during hemorrhagic shock/resuscitation
50. Protective effect of pentoxifylline on gastric mucosa