Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201

Antiviral Research

Volumn 51, Issue 3, 2001, Pages 179-187

  Sidwell, Robert W ^a   Smee, Donald F ^a   Huffman, John H ^a   Barnard, Dale L ^a   Morrey, John D ^a   Bailey, Kevin W ^a   Feng, W C ^a   Babu, Y S ^b   Bush, Karen ^c  

^a UTAH STATE UNIVERSITY   (United States)

^b BIOCRYST PHARMACEUTICALS INC   (United States)

^c R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Antiviral; Influenza virus; Neuraminidase inhibitor; RWJ 270201

Indexed keywords

OXYGEN; PERAMIVIR; SIALIDASE INHIBITOR; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTERIAL OXYGEN TENSION; ARTICLE; CONTROLLED STUDY; DEATH; DETERIORATION; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; EXPOSURE; FEMALE; INFLUENZA; INFLUENZA VIRUS; INFLUENZA VIRUS A; INHIBITION KINETICS; LETHAL DOSE; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; STRAIN DIFFERENCE; VIRUS STRAIN; VIRUS TITRATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GUANIDINES; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MICE; MICE, INBRED BALB C; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS;

INFLUENZA VIRUS; MURINAE;

EID: 0034942258     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00149-8     Document Type: Article

References (9)

1. BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
2. Comparison of the antiinfluenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir
3. Anti-influenza A activity of combination of amantadine and ribavirin in ferret tracheal ciliated epithelium
4. Safety and efficacy of an oral neuraminidase inhibitor RWJ-270201 in treating experimental influenza A and B in healthy adult volunteers
5. Activity of selenazofurin against influenza A and B virus infections in mice
6. Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice
7. Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
8. In vivo influenza-inhibitory effects of the cyclopentane neuraminidase inhibitor RWJ-270201
9. Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activity