Selective inactivation of Von Willebrand factor binding to glycoprotein IIb/IIIa and to inhibitor monoclonal antibody 9 by site-directed mutagenesis

Hematology Journal

Volumn 2, Issue 3, 2001, Pages 180-187

  Jumilly, A L ^a   Veyradier, A ^a   Ribba, A S ^a   Meyer, D ^a   Girma, J P ^a  

^a Dept Environ Med Natl Inst Publ HIth   (Norway)

Author keywords

Monoclonal antibody; Mutations; RGD binding site; Von Willebrand factor; VWF GPIIb IIIa interaction

Indexed keywords

ALANINE; ARGININE; ARGINYLGLYCYLASPARTIC ACID; BETA3 INTEGRIN; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; LYSINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 9; POLYMER; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INHIBITION KINETICS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; THROMBOCYTE ACTIVATION;

AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES; BIOPOLYMERS; BLOOD PLATELETS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; VON WILLEBRAND FACTOR;

EID: 0034941895     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200093     Document Type: Article

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