Synthesis and preliminary pharmacological evaluation of 5-Hydroxy- and 5,6-dihydroxy-1,2,3,7,12,12a-hexahydrobenzo[5,6]cyclohepta[1,2,3-ij]isoquinoline derivatives as dopamine receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 6, 2001, Pages 1447-1458

  Cingolani, Gian Mario ^a   Di Stefano, Antonio ^b   Napolitani, Fabrizio ^a   Mosciatti, Barbara ^a   Giorgioni, Gianfabio ^a   Cinone, Nunzia ^b   Brunetti, Luigi ^b   Luisi, Grazia ^b   Michelotto, Barbara ^b   Orlando, Giustino ^b   Costa, Barbara ^c   Lucacchini, Antonio ^c   Martini, Claudia ^c   Claudi, Francesco ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR; ISOQUINOLINE DERIVATIVE; SPIPERONE;

ADENOHYPOPHYSIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PROLACTIN RELEASE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; CYCLOHEPTANES; DOPAMINE AGONISTS; DRUG EVALUATION, PRECLINICAL; ISOQUINOLINES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MONTE CARLO METHOD; PITUITARY GLAND, ANTERIOR; PROLACTIN; RATS; RECEPTORS, DOPAMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034941411     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00016-5     Document Type: Article

References (20)