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Volumn 49, Issue 7, 2001, Pages 830-839
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Structure-activity relationships of n-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N′-(3,4-dimethylphenyl) piperazine and analogues as inhibitors of acyl-CoA: Cholesterol O- acyltransferase
a
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Author keywords
Acyl CoA; Amide compound; Cholesterol O acyltransferase inhibitor; Hypocholesterolemic activity; Structure activity relationship study; Yakuchinone B
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Indexed keywords
1 (2,6 DIISOPROPYL) 3 [[1 [4 (DIMETHYLAMINO)PHENYL]CYCLOPENTYL]METHYL]UREA;
2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE;
3 (2,4 DIFLUOROPHENYL) 1 HEPTYL 1 (4 NEOPENTYLBENZYL)UREA;
CHOLESTEROL ACYLTRANSFERASE;
CHOLESTEROL ACYLTRANSFERASE INHIBITOR;
N (1,2 DIPHENYLETHYL) 2 OCTYLOXYPHENYLACETAMIDE;
N (3,5 DIMETHOXY 4 N OCTYLOXYCINNAMOYL) N' (3,4 DIMETHYLPHENYL)PIPERAZINE;
N (3,5 DIMETHOXY 4 N OCTYLOXYCINNAMOYL) N' (3,4 DIMETHYLPHENYL)PIPERAZINE DERIVATIVE;
UNCLASSIFIED DRUG;
YM 750;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ARTICLE;
CELL STRAIN CACO 2;
CELL STRAIN HEPG2;
CHOLESTEROL METABOLISM;
CONTROLLED STUDY;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
HYPERCHOLESTEROLEMIA;
LIVER MICROSOME METABOLISM;
NONHUMAN;
RAT;
STRUCTURE ACTIVITY RELATION;
ANIMALS;
ANTICHOLESTEREMIC AGENTS;
CACO-2 CELLS;
CHOLESTEROL;
CHOLESTEROL, DIETARY;
CINNAMATES;
ENZYME INHIBITORS;
HUMANS;
LIVER NEOPLASMS, EXPERIMENTAL;
MALE;
MICROSOMES, LIVER;
PIPERAZINES;
RATS;
RATS, SPRAGUE-DAWLEY;
STEROL O-ACYLTRANSFERASE;
STRUCTURE-ACTIVITY RELATIONSHIP;
TUMOR CELLS, CULTURED;
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EID: 0034935946
PISSN: 00092363
EISSN: None
Source Type: Journal
DOI: 10.1248/cpb.49.830 Document Type: Article |
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Times cited : (11)
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References (46)
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