The relationship between radiation-induced G1 arrest and chromosome aberrations in Li-Fraumeni fibroblasts with or without germline TP53 mutations

British Journal of Cancer

Volumn 85, Issue 2, 2001, Pages 293-296

  Boyle, J M ^a   Spreadborough, A ^a   Greaves, M J ^a   Birch, J M ^b   Varley, J M ^a   Scott, D ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

Chk2; Chromosome aberrations; Fibroblasts; G1 arrest; Ionizing radiation; Li Fraumeni syndrome; p53

Indexed keywords

DNA;

ARTICLE; CANCER SUSCEPTIBILITY; CELL CYCLE G1 PHASE; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA STRAND BREAKAGE; FAMILIAL CANCER; FIBROBLAST CULTURE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

CHROMOSOME ABERRATIONS; G1 PHASE; GENES, P53; GERM-LINE MUTATION; HUMANS; LI-FRAUMENI SYNDROME;

EID: 0034935176     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1896     Document Type: Article

References (24)

1. Heterozygous germline mutations in hCHK2 are a cause of Li-Fraumeni syndrome
2. Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families
3. 1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations
4. Chromosome instability in fibroblasts derived from Li-Fraumeni syndrome families without TP53 mutations
5. A possible screening test for inherited p53-related defects based on apoptotic response of peripheral blood lymphocytes to DNA damage
6. 1 by stabilizing p53
7. Human fibroblasts expressing the human papillomvirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation
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13. 2-phase X-irradiation in relation to DNA repair and radiosensitivity in a cancer-prone family with Li-Fraumeni syndrome
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