Reduced TIGR/myocilin protein in the monkey ciliary muscle after topical prostaglandin F2α treatment

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 8, 2001, Pages 1781-1786

  Lindsey, J D ^a   Gaton, D D ^a   Sagara, T ^a   Polansky, J R ^a   Kaufman, P L ^a   Weinreb, R N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; LEUCINE ZIPPER PROTEIN; MYOCILIN; PARAFFIN; POLYCLONAL ANTIBODY; PROSTAGLANDIN F2 ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR FLOW; ARTICLE; CILIARY MUSCLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DENSITOMETRY; DISEASE MODEL; DRUG EFFECT; GLAUCOMA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAOCULAR HYPOTENSION; MONKEY; MUSCLE LEVEL; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE SECTION;

ADMINISTRATION, TOPICAL; ANIMALS; CILIARY BODY; CYTOSKELETAL PROTEINS; DINOPROST; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCOPROTEINS; INTRAOCULAR PRESSURE; MACACA FASCICULARIS; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH;

EID: 0034934604     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Eicosanoid production and glucocorticoid regulatory mechanisms in cultured human trabecular meshwork cells
2. Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product
3. The TIGR gene, pathogenic mechanisms, and other recent advances in glaucoma genetics
4. Identification of a gene that causes primary open angle glaucoma
5. Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)
6. Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma
7. Juvenile open angle glaucoma: Fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis
8. GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein
9. Myocilin and glaucoma: A TIGR by the tail?
10. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: Molecular cloning, tissue expression, and chromosomal mapping
11. Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A)
12. Localization of the stress proteins alpha B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork
13. Localization of myocilin/trabecular meshwork-inducible glucocorticoid response protein in the human eye
14. Regulation of human myocilin/TIGR gene transcription in trabecular meshwork cells and astrocytes: Role of upstream stimulatory factor
15. Ultrastructural localization of myocilin in human trabecular meshwork cells and tissues
16. Gene structure and properties of TIGR, an olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells
17. Immunofluorescence method for quantifying the trabecular meshwork glucocorticoid response (TIGR) protein in trabecular meshwork and Schlemm's canal cells
18. 2α treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway
19. Effects of prostaglandins on uveoscleral outflow
20. Prostaglandins alter extracellular matrix adjacent to human ciliary muscle cells in vitro
21. Quantitative immunocytochemistry of hypothalamic and pituitary hormones: Validation of an automated, computerized image analysis system
22. Quantification in immunohistochemistry: The measurement of the ratios of collagen types I and II
23. Matrix metalloproteinase-1 localization in the normal human uveoscleral outflow pathway
24. Self-assembly of basement membrane collagen
25. Basement membrane (type IV) collagen
26. Uveoscleral permeability to intracamerally infused ferritin in eyes of rabbits and monkeys
27. Conventional and uveoscleral drainage of aqueous humour in the cynomolgus monkey (Macaca irus) at normal and high intraocular pressures
28. Uveoscleral drainage of aqueous humor: Physiology and pharmacology
29. 2α
30. 2α. An ultrastructural study in rhesus and cynomolgus monkeys
31. Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells
32. Prostaglandins increase metalloproteinase activity in medium of hüman ciliary smooth muscle cells in vitro
33. Proteinases and matrix degradation
34. Effect of prostaglandins on cyclic AMP production in cultured human ciliary muscle cells
35. Cloning and expreSsion of a cDNA for the human prostanoid FP receptor
36. 2α receptor