Glucose-induced insulin secretion is potentiated by a new imidazoline compound

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 1, 2001, Pages 47-52

  Mest, H J ^a   Raap, A ^a   Schloos, J ^a   Treinies, I ^a   Paal, M ^a   Giese, U ^a   Koivisto, V ^a  

^a Lilly Research Laboratories   (Germany)

Author keywords

Glucose tolerance; Glucose dependent insulin secretion; Imidazoline; Islets; LY389382; ZDF rats; Cells

Indexed keywords

2 [4 (4 CHLOROPHENYL) 3 (2 METHOXYETHOXY) 2 NAPHTHALENYL] 4,5 DIHYDRO 1H IMIDAZOLE; IMIDAZOLINE DERIVATIVE; LY 389382; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DERIVATIZATION; DRUG POTENTIATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HYPOGLYCEMIA; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; RECEPTOR BLOCKING;

ANIMALS; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; IMIDAZOLES; INSULIN; ISLETS OF LANGERHANS; MALE; MOLECULAR STRUCTURE; NAPHTHALENES; RATS; RATS, WISTAR; RATS, ZUCKER;

EID: 0034933337     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100415     Document Type: Article

References (13)

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8. Imidazoline receptors: New targets for antihyperglycemic drugs
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10. ATP channels is mediated by Kir6.2
11. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N′-(arylalkyl)-2-(4′,5′-dihydro-1′-H- imidazol-2′-yl)piperazines
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13. Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery