Metronidazole-resistant strains of Trichomonas vaginalis display increased susceptibility to oxygen

Parasitology

Volumn 123, Issue 1, 2001, Pages 45-56

  Rasoloson, D ^a   Tomkova E ^a   Cammack, R ^b   Kulda, J ^a   Tachezy, J ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Ferredoxin; Metronidazole resistant Trichomonas vaginalis; NADH oxidase; Oxygen sensitivity; Superoxide dismutase

Indexed keywords

FERREDOXIN; METRONIDAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUPEROXIDE DISMUTASE;

ANAEROBIC METABOLISM; ARTICLE; NONHUMAN; OXIDATIVE STRESS; OXYGENATION; PARASITE ISOLATION; PARASITE SURVIVAL; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS;

ANIMALS; ANTITRICHOMONAL AGENTS; BLOTTING, WESTERN; DRUG RESISTANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; FERREDOXINS; HUMANS; METRONIDAZOLE; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; OXYGEN; SUPEROXIDE DISMUTASE; TRICHOMONAS VAGINALIS; TRICHOMONAS VAGINITIS;

PROTOZOA; TRICHOMONAS VAGINALIS;

EID: 0034932513     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182001008022     Document Type: Article

References (50)

1. Removal of hydrogen peroxide by the 29 kDa protein of Entamoeba histolytica
2. Respiration of hydrogenosomes of Tritrichomonas foetus
3. Metabolic differences between metronidazole resistant and susceptible strains of Tritrichomonas foetus
4. Metabolic properties of Trichomonas vaginalis resistant to metronidazole under anaerobic conditions
5. Respiration of Trichomonas vaginalis. Components detected by electron paramagnetic resonance spectroscopy
6. Factors affecting the trichomonacidal activity of metronidazole
7. The establishment of various trichomonads of animals and man in axenic cultures
8. Glutathione transferase activity in some flagellates and amoeba, and purification of the soluble glutathione transferases from Acanthamoeba
9. Iron-ascorbate cleavable malic enzyme from hydrogenosomes of Trichomonas vaginalis: Purification and characterization
10. Nitroimidazole drugs-action and resistance mechanisms. II. Mechanisms of resistance
11. Influence of oxygen on the fermentative metabolism of metronidazole-sensitive and resistant strains of Trichomonas vaginalis
12. Antioxidant defences in the microaerophilic protozoan Trichomonas vaginalis: Comparison of metronidazole-resistant and sensitive strains
13. Entamoeba histolytica: A eukaryote without glutathione metabolism
14. Correlation between aerobic and anaerobic resistance to metronidazole in trichomonads: Application of new computer program for permutation tests
15. Metronidazole-resitant Trichomonas vaginalis
16. Clonal growth of Entamoeba histolytica and other Entamoeba in agar
17. Induction of superoxide dismutase by molecular oxygen
18. - induced manganese-containing superoxide dismutase from Bacteroides fragilis
19. An iron-containing superoxide dismutase in Tritrichomonas foetus
20. Trichomonads, hydrogenosomes and drug resistance
21. Tritrichomonas foetus: Stable anaerobic resistance to metronidazole in vitro
22. In vitro induced anaerobic resistance to metronidazole in Trichomonas vaginalis
23. Metronidazole resistance of Trichomonas vaginalis as a cause of treatment failure in trichomoniasis. A case report
24. Beta-succinyl-coenzyme. A synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequences
25. Superoxide dismutase in the anaerobic flagellates, Tritrichomonas foetus and Monocercomonas sp
26. The purification and properties of two soluble reduced nicotinamide: Acceptor oxidoreductases from Trichomonas vaginalis
27. Ferredoxin involvement in metronidazole resistance of Giardia duodenalis
28. In vitro drug susceptibility and doses of metronidazole required for cure in cases of refractory vaginal trichomoniasis
29. Effect of oxygen and carbon dioxide on the growth of Trichomonas vaginalis and Tritrichomonas foetus
30. Superoxide dismutase: An enzymic function for erythrocuprein (hemocuprein)
31. Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles
32. Assay conditions and the demonstration of nitroimidazole resistance in Tritrichomonas foetus
33. Biochemical cytology of trichomonad flagellates. I. Subcellular localization of hydrolases, dehydrogenases, and catalase in Tritrichomonas foetus
34. Reductive activation of nitroimidazoles in anaerobic microorganisms
35. Metabolism and metronidazol uptake in Trichomonas vaginalis isolates with different metronidazole susceptibilities
36. Three metronidazole resistant strains of Trichomonas vaginalis from the United States
37. Tritrichomonas foetus and Trichomonas vaginalis: The pattern of inactivation of hydrogenase activity by oxygen and activities
38. Trichomonas vaginalis requires traces of oxygen and high concentrations of carbon dioxide for optimal growth
39. Evidence for an [Fe]-type hydrogenase in the parasitic protozoan Trichomonas vaginalis
40. Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis
41. Studies of metabolism of the protozoa. 5. Metabolism of the parasitic flagellate Tritrichomonas foetus
42. Involvement of superoxide dismutase and pyruvate: Ferredoxin oxidoreductase in mechanisms of metronidazole resistane in Entamoeba histolytica
43. Aerobic resistance of Trichomonas vaginalis to metronidazole induced in vitro
44. Trichomonas vaginalis: NADH oxidase activity
45. Trichomonas species: Homocysteine desulphurase and serine sulphydrase activities
46. L-methionine catabolism in trichomonads
47. Oxygen tension of the vaginal surface during sexual stimulation in the human
48. Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase
49. Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis
50. Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities