Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant

Bone Marrow Transplantation

Volumn 27, Issue 12, 2001, Pages 1283-1286

  Robertson, J D ^a   Testa, N G ^a   Russell, N H ^b   Jackson, G ^c   Parker, A N ^d   Milligan, D W ^e   Stainer, C ^b   Chakrabarti, S ^e   Dougal, M ^a   Chopra, R ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^c ROYAL VICTORIA INFIRMARY   (United Kingdom)

^d GLASGOW ROYAL INFIRMARY   (United Kingdom)

^e BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

Allogeneic; Telomere; Transplantation

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; MELPHALAN;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BLOOD CELL; BONE MARROW; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LYMPHOCYTE HOMING; MEDICAL DOCUMENTATION; NEUTROPHIL; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RECIPIENT; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; TELOMERE; THROMBOCYTE;

ADOLESCENT; ADULT; AGED; BLOOD CELLS; BONE MARROW TRANSPLANTATION; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MIDDLE AGED; NEUTROPHILS; T-LYMPHOCYTES; TELOMERE; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0034932138     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703069     Document Type: Article

References (24)

1. In vivo telomere dynamics of human hematopoietic stem cells
2. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants
3. Changes of telomere length in children after hematopoietic stem cell transplantation
4. Telomere length changes in patients undergoing hematopoietic stem cell transplantation
5. Telomere shortening in leucocyte subsets of long-term survivors of allogeneic bone marrow transplantation
6. Peripheral blood vs bone marrow as a source for allogeneic hematopoietic stem cell transplantation
7. Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: First results of a randomised multicentre trial of the European Group for Marrow Transplantation
8. Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow
9. Characterization of CD34+ peripheral blood cells from healthy adults mobilized by recombinant human granulocyte colony-stimulating factor
10. CD34+ cell dose predicts survival, post transplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies
11. Cycling status of CD34+ cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte colony-stimulating factor
12. Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor
13. The mobilization of primitive hemopoietic progenitors into the peripheral blood
14. The fluctuating phenotype of the lymphohematopoietic stem cell with cell cycle transit
15. Lymphohematopoietic stem cell engraftment
16. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
17. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
18. Dynamics of telomere shortening in neutrophils and T cells during ageing and the relationship to skewed X chromosome inactivation patterns
19. Allogeneic blood stem cell transplantation: Peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+Thyldim) and lymphoid subsets, and possible predictors of engraftment and disease
20. + cells mobilized into peripheral blood
21. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life
22. Human naive and memory T lymphocytes differ in telomeric length and replicative potential
23. Behavior of haemopoietic stem cells in a large animal
24. Blood stem cells versus bone marrow as a source of haematopoietic cells for allogeneic transplantation