JTV-519 Japan tobacco

Current Opinion in Investigational Drugs

Volumn 2, Issue 7, 2001, Pages 936-939

  Tse, H F ^a   Lam, W F ^a  

^a QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; ANTIARRHYTHMIC AGENT; BENZODIAZEPINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CATECHOLAMINE; DILTIAZEM; DOFETILIDE; ION CHANNEL; JTV 201; LIPOCORTIN 5; NICORANDIL; POTASSIUM CHANNEL BLOCKING AGENT; PRAZOSIN; PROPRANOLOL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SODIUM CHANNEL BLOCKING AGENT; SOTALOL; UNCLASSIFIED DRUG; VERAPAMIL;

ANTIARRHYTHMIC ACTIVITY; CALCIUM CURRENT; CLINICAL TRIAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG CLASSIFICATION; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; DRUG USE; HEART ARRHYTHMIA; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; REPERFUSION INJURY; REVIEW; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; STUNNED HEART MUSCLE; TOXICITY TESTING;

ANIMALS; ANNEXIN A5; ANTI-ARRHYTHMIA AGENTS; CALCIUM; CARDIOTONIC AGENTS; CELL DEATH; ION CHANNELS; MEMBRANE POTENTIALS; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; MYOCARDIUM; PROTEIN KINASE C; THIAZEPINES;

EID: 0034926648     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. New 1,4-benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death and intracellular calcium blocking action
2. Inhibition of kinetic cell death and effects on cardiac function of K-201, a novel 1,4 benzothiazepine derivative
3. 2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivative
4. Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor
5. Effects of JTV-519, a new organ-protective drug, on cardiovascular system
6. Effects of a novel cardioprotective drug JTV-519 on membrane currents of single ventricular cells of the guinea pig heart
7. Protective action of β-blockade and JTV-519 on SAH heart muscle
8. 2+ overload
9. Anti-stunning effects of JTV-519 in coronary perfused guinea pig ventricular muscles
10. Novel cardioprotective agent, JTV519, confers ischemic preconditioning-like effects through specific activation of delta-protein kinase C
11. Anti-ischemic effect of JTV-519, a new cardioprotective drug, in dogs
12. Novel cardioprotective agent, JTV-519, confers ischemic preconditioning-like effects through specific activation of delta-protein kinase C
13. Drug development pipeline: JTV-519
14. Drug development pipeline: JTV-519
15. Annual report 1999 - Japan Tobacco Inc.
16. Anti-ischemic effect of a novel cardioprotective agent, JTV519, is mediated through specific activation of delta-isoform of protein kinase C in rat ventricular myocardium
17. JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular muscles
18. + current in guinea-pig ventricular myocytes
19. Protective effect of JTV519 on prolonged myocardial preservation
20. Protective effect of JTV519 (K201), a new 1,4-benzothiazepine derivative, on prolonged myocardial preservation
21. Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes
22. Protective effect of JTV519, a new 1,4-benzothiazepine derivative, on prolonged myocardial preservation
23. + current and experimental atrial fibrillation in the guinea-pig heart
24. Effects of a novel cardioprotective drug JTV-519 on membrane currents of single ventricular cells of the guinea pig heart
25. Effect of JTV-519, a new organ-protective drug, on cardiovascular system
26. 2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothazepine derivative
27. + exchange inhibitors
28. Effects of a novel cardioprotective drug JTV-519 on membrane currents of single ventricular cells of the guinea pig heart
29. Effect of JTV-519, a new organ-protective drug, on cardiovascular system
30. Calcium channel blocking activity of JTV-519, a novel protective drug to cytotoxicity
31. Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts
32. Effect of a novel cardioprotective agent, JTV-519, on metabolism, contraction and relaxation in the ischemia-reperfused rabbit heart
33. 2+ overload in isolated rat hearts