New treatments for concussion: The next millennium beckons

Clinical Journal of Sport Medicine

Volumn 11, Issue 3, 2001, Pages 190-193

  McCrory, Paul ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NONE   (Australia)

Author keywords

Concussion; Drug therapy; Pharmacology; Traumatic brain injury

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; CORTICOSTEROID; GLUTAMATE RECEPTOR ANTAGONIST; IBUPROFEN; METHYLPREDNISOLONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTROPHIC FACTOR; OPIATE ANTAGONIST; OXYGEN; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTIRELIN; PROTIRELIN DERIVATIVE; SCAVENGER; THROMBOXANE DERIVATIVE; TIRILAZAD;

ARTICLE; BRAIN CONCUSSION; BRAIN INJURY; DRUG EFFICACY; DRUG MECHANISM; EVIDENCE BASED MEDICINE; HUMAN; INDUCED HYPOTHERMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ATHLETIC INJURIES; BRAIN CONCUSSION; FORECASTING; HUMANS;

EID: 0034926506     PISSN: 1050642X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042752-200107000-00010     Document Type: Article

References (36)

1. Traumatically induced axonal damage: Evidence for enduring changes in axolemmal permeability with associated cytoskeletal change
2. The neurochemical and metabolic cascade following brain injury: Moving from animal models to man
3. Role of excitatory amino acids-mediated ionic fluxes in traumatic brain injury
4. Expression of the basic fibroblast growth factor gene in mild and more severe head injury in the rat
5. Involvement of cytokines in normal CNS development and neurological diseases: Recent progress and perspectives
6. Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain
7. Slowing of cerebral circulation following concussional head injury: Its relationship to symptoms and the etiology of concussion
8. Aetiology and treatment of post concussion syndrome
9. Diffuse cerebral swelling following head injuries in children: The syndrome of "malignant brain oedema."
10. The aetiology of acute brain swelling following experimental brain injury
11. Experimental cerebral concussion
12. Diffuse axonal injury due to non-missile head injury in humans: An Analysis of 45 cases
13. Novel pharmacological therapies in the treatment of experimental traumatic brain injury: A review
14. High dose methyl prednisolone and CNS injury
15. A randomised controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury
16. Effect of the 21-amino steroid U-74006F on experimental head injury in mice
17. Effect of D1 alpha tocopherol succinate and polyethylene glycol on performance tests after fluid percussion brain injury
18. Compression induced brain edema: Modification by prior depletion and supplementation of vitamin E
19. Combined PG12, indomethacin and heparin improves neurological recovery after spinal trauma in cats
20. Changes in cortical extracellular levels of energy related metabolites and amino acids following concussive brain injury in rats
21. A randomised trial of nimodipine in severe head injury
22. A double blind placebo controlled trial of the calcium entry blocking drug nicardipine in the treatment of vasospasm following severe head injury
23. (S)-emopamil attenuates acute reduction in regional cerebral blood flow following experimental brain injury
24. Effects of timing of methyl prednisolone or naloxone administration on recovery of segmental and long tract neurological function in NASCIS2
25. TRH in experimental spinal cord injury
26. Beneficial effect of the nonselective opiate antagonist naloxone hydrochloride and the TRH analogue YM-14673 on long-term neurobehavioural outcome following experimental brain injury in the rat
27. Comparison of single versus combination drug strategies in experimental brain trauma
28. Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy
29. Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury
30. Intravenous insulin-like growth factor- 1 (IGF-1) in moderate-to-severe head injury: A phase II safety and efficacy trial
31. Bcl-2 promotes regeneration of severed axons in the mammalian CNS
32. Hypothermia accentuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat
33. Results of a prospective randomised trial for the treatment of severely brain injured patients with hyperbaric oxygen
34. Improved recovery from a traumatic hypoxic brain injury in cats by intracisternal injection of an anion transport inhibitor
35. Dietary supplement creatine protects against traumatic brain injury