Platelet glycoproteins and their role in diseases

Transfusion Clinique et Biologique

Volumn 8, Issue 3, 2001, Pages 155-162

  Clemetson, K J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Bernard Soulier syndrome; Glanzmann's thrombasthenia; Idiopathic thrombocytopenia purpura; Platelet receptors; Receptor polymorphisms

Indexed keywords

HEPARIN; THROMBIN RECEPTOR; THROMBOCYTE ANTIBODY; THROMBOCYTE RECEPTOR;

ASTHMA; AUTOIMMUNITY; BERNARD SOULIER DISEASE; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DIABETES MELLITUS; DISEASE PREDISPOSITION; GENETIC POLYMORPHISM; GLANZMANN DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; PATHOGENESIS; PROTEIN ANALYSIS; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA;

EID: 0034925356     PISSN: 12467820     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1246-7820(01)00184-7     Document Type: Conference Paper

References (51)

1. Cloning of the alpha chain of human platelet glycoprotein Ib: A transmembrane protein with homology to leucine-rich alpha 2- glycoprotein
2. The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence
3. Human platelet glycoprotein IX: An adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures
4. Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation
5. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and do not exhibit a Bernard-Soulier phenotype
6. Increased thrombin responsiveness in platelets from mice lacking glycoprotein V
7. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V
8. Bernard-Soulier syndrome
9. Inherited abnormalities of platelets
10. Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ibα leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease
11. Reduced thrombin binding and aggregation in Bernard-Soulier platelets
12. Platelet prothrombin converting activity in hereditary disorders of platelet function
13. Binding of thrombin to the Glycoprotein Ib accelerates the hydrolysis of PAR-1 on intact platelets
14. Platelet glycoprotein Ib-alpha binds to thrombin anion-binding exosite II inducing allosteric changes in thrombin's activity
15. The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity
16. Point mutation in a leucine-rich repeat of platelet glycoprotein Ibα resulting in the Bernard-Soulier syndrome
17. Role of the leucine-rich domain of platelet GPIbalpha in correct post-translational processing-the Nancy I Bernard-Soulier mutation expressed on CHO cells
18. Hereditäre hämorrhahagische thrombasthenie: Ein beitrage zur pathologie der blutplättchen
19. An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia
20. Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes
21. Platelet glycoprotein IIb/IIIa receptors and Glanzmann's thrombasthenia
22. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
23. Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder
24. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors
25. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia
26. Molecular basis of CD36 deficiency. Evidence that a 478C → T substitution (proline 90→ serine) in CD36 cDNA accounts for CD36 deficiency
27. Acquired thrombasthenia due to GPIIb/IIIa-specific platelet autoantibodies
28. Acquired Bernard-Soulier syndrome. Evidence for the role of a 210,000-molecular weight protein in the interaction of platelets with von Willebrand factor
29. The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIA, and are distinguishable by DNA typing
30. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis
31. The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions
32. Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa)
33. Platelet glycoprotein IIb polymorphism, traditional risk factors and non-fatal myocardial infarction in young women
34. HPA-1 and HPA-3 polymorphisms of the platelet fibrinogen receptor and coronary artery disease and myocardial infarction
35. b are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit α2)
36. 2 subunit of VLA-2)
37. Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: A case-control study
38. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients
39. The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients
40. The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction
41. Glycoprotein Ia gene C807T polymorphism and risk for major adverse cardiac events within the first 30 days after coronary artery stenting
42. Platelet glycoprotein Ia gene dimorphism alpha in malignant arrhythmia in coronary artery disease
43. Genetic variants of platelet glycoprotein receptors and risk of stroke in young women
44. Homozygosity for 807 T polymorphism in alpha(2) subunit of platelet alpha(2)beta(1) is associated with increased risk of cardiovascular mortality in high-risk women
45. NH2-terminal globular domain of human platelet glycoprotein Ib alpha has a methionine 145/threonine145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens
46. Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications
47. Stroke and platelet glycoprotein Ibalpha polymorphisms
48. T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction
49. Hereditary thrombocytopenia clue to reduced platelet production-report on two families and mutational screening of the thrombopoietin receptor gene (c-mpl)
50. Molecular basis for a polymorphism of human Fc gamma receptor II (CD32)
51. Low platelet alpha2beta1 levels in type I von Willebrand disease correlate with impaired platelet function in a high shear stress system