Does α-1-proteinase inhibitor play a protective role in coronary atherosclerosis?

Medical Science Monitor

Volumn 7, Issue 4, 2001, Pages 701-711

  Stakisaitis, Donatas ^a   Basys, Vytautas ^a   Benetis, Rimantas ^b  

^a VILNIUS UNIVERSITY   (Lithuania)

^b Kaunas Academic Clinic of Cardiac Surgery   (Lithuania)

Author keywords

1 proteinase inhibitor; Aging; Atherogenesis; Dysapolipoproteinaemia

Indexed keywords

ALPHA 1 ANTITRYPSIN; PROTEINASE; PROTEINASE INHIBITOR;

ADULT; ARTICLE; ATHEROGENESIS; CORONARY ARTERY ATHEROSCLEROSIS; CORRELATION FUNCTION; HUMAN; HYPERLIPIDEMIA; MAJOR CLINICAL STUDY; MALE; PHENOTYPE;

ADULT; AGED; AGED, 80 AND OVER; ALPHA 1-ANTITRYPSIN; CASE-CONTROL STUDIES; CHILD; CORONARY ARTERIOSCLEROSIS; HUMANS; MALE; MIDDLE AGED; PHENOTYPE;

EID: 0034924088     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (100)

1. Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease
2. The pathogenesis of atherosclerosis: A perspective for 1990s
3. Elastase-type acticity, elastase inhibitor capacity, lipids and lipoproteins in the sera of patients with ischemic vascular disease
4. Variation of elastase-type protease activity and elastin biosynthesis in rabbit aorta induced by cholesterol diet and immunization with elastin peptides
5. Human aortic elastin from normal individuals and atherosclerotic patients: Lipid and cation contents; susceptibility to elastolysis
6. Activity of leukocyte elastase in coronary disease diagnosed by coronarography
7. Regulation of fibrinolytic activity of neutrophil leukocyte elastase, plasmin and miniplasmin by plasma protease inhibitors
8. Total and differential leukocyte counts as predictors of ischemic heart disease
9. Plasma leukocyte elastase concentration in agiographically diagnosed coronary artery disease
10. Plasma leukocyte elastase concentration and coronary artery disease
11. The circulating alpha-1-anti-trypsin-elastase complex attacks the elastic lamina of blood vessels. An Immunohistochemical Study
12. Elastin-elasrase-aterosclerosis revisited
13. Endothelial serpins - Protectors of the vasculitis?
14. Connective tissue changes in atherosclerosis
15. Elastin, elastase and atherosclerosis
16. Quantitative changes of proteinase inhibitors in patients with atherosclerosis of coronary arteries
17. Studies in alpha 1-antitrypsin deficiency
18. Alpha-1-antitrypsin aus human serum
19. Elastase: Catalytic and biological properties
20. Human alpha 1-proteinase inhibitor
21. Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha-1-antitrypsin and alpha-2-macroglobulin
22. Effect of aging on human aortic protein composition. II. Two-dimentional polyacrylamide gel electrophoretic analysis
23. Quantitative alteration of some aortic intima proteins in fatty streaks and fibro-fatty lessions
24. Structure and variations of human alpha-1-antitrypsin
25. Genetics of alpha-1-antitrypsin
26. Arterial fibromuscular dysplasia associated with severe alpha 1-antitrypsin deficiency
27. Frequency of deficient genetic variants of alpha-1-proteinase inhibitor in Lithuanian population
28. Elastin structure, biosynthesis, and relation to disease states
29. Correlation between age, arteriosclerosis and elastolytic activity of human aorta wall
30. Elastase-like enzymes in aortas and human breast carcinomas: Quantitative variations with age and pathology
31. Human aortic intima protein composition during initial stages of atherogenesis
32. Protein distribution across the human atherosclerotic wall with reference to immunoglobulins and complements
33. Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement
34. Effects of human neutophil elastase (HNE), neutrophil function in vitro and in inflamed microvessels
35. Reperfusion-induced leukocyte infiltration: Role of elastase
36. Lipoproteins, elastase and atherogenesis
37. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
38. Stimulation of leukocyte/endothelium interaction by oxidized low density lipoprotein in hairless mice, involvement of CD11b/CD18 adhesion receptor complex
39. Alpha-1-antitrypsin in pancreatitis
40. Determination of alpha-1-antitrypsin subtypes in the population of Rome. A study in ultrathin-layer isoelectric focusing
41. Activity of elastase-like proteinases and their inhibitors in indigent nearly healthy residents in various biogeochemical conditions of the Chuvash ASSR
42. The electrophoretic 1-globulin pattern of serum in 1-antitrypsin deficiency
43. Cirrhosis associated with alpha-1-antitrypasin deficiency: A previously unrecognized disorder
44. DNA restriction fragments associated with alpha-1-antitrypsin indicate a single origin for deficiency allele PI Z
45. Alpha-1-antitrypsin: Molecular pathology, leukocytes, and tissue damage
46. The relationship between concentration of blood serum alpha-1-proteinase inhibitor and phenotypes of alpha-1-proteinase inhibitor
47. Protease inhibitors in plasma. Chap 5
48. Longitudinal lung function study in the heterozygous PiMZ phenotype subjects
49. The effect of the Z mutation on the ability of alpha-1-antitrypsin to prevent neutrophil mediated tissue damage
50. Human alpha-1-proteinase inhibitor binds to extracellular matrix in vivo
51. The effect of age on the relationship between plasma elastase and ingested lipid
52. Neutrophils obtained from obliterative atherosclerotic patients exhibit enhanced resting respiratory burst and increased degranulation in response to variuos stimuli
53. Polymorphonuclear leukocytes enhance release of growth factors by cultured endothelial cells
54. Cutaneous aging. Its relation with arteriosclerosis and atheroma
55. Aging of vascular wall and atherogenesis, role of the elastin-laminin receptor
56. Serum elastase inhibitors in cardiovascular diseases
57. Serum glycoproteins and severity of coronary atherosclerosis
58. Structural changes of high-density-lipoproteins following incubation with human polymorphonuclear cells
59. Elastase-type enzymes and their relation to blood lipids in the atherosclerotic patients
60. Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins
61. A receptor-mediated path way for cholesterol homeostasis
62. Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein
63. Immunomodulating effect of low density lipoprotein on human monocytes
64. Lipoprotein-elastin interaction in human aorta fibrous plaque lesions
65. Elastin sub-fraction as binding site for lipids
66. Interaction of serum and arterial lipoproteins with elastin of the arterial intima and its role in the lipid accumulation in atherosclerotic plaques
67. In viva complex formation between cholesterol and alpha 1-proteinase inhibitor
68. Conformational changes of the alpha 1-proteinase inhibitor affecting its cholesterol binding ability
69. Oxidation of alpha-1-proteinase inhibitor: Role of lipid peroxidation products
70. Evaluation of elastin metabolism in children from families with high risk of atherosclerosis
71. Aging of the vascular wall: Serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA Study
72. Atherosclerosis and aneurysm of aorta in relation to smoking habits and age
73. The influence of smoking on serum trypsin inhibitory capacity and alpha 1-antitrypsin
74. Cigarette smoke inhalation decreases alpha-1-antitrypsin activity in rat lung
75. Tobacco smoking and other factors in relation to serum alpha-1-antitrypsin
76. Vitamin E, pulmonary functions, and phagocyte-mediated oxidative stress in smokers and nonsmokers
77. Smoking and leukocyte-counts: Results of an epidemiological survey
78. Cigarette smoking, emphysema, and damage of alpha 1-proteinase inhibitor
79. Kinetics of association of serine proteinases with native and oxidized alpha 1-proteinase inhibitor and plasma alpha 1-antichymotrypsin
80. Proteases, antiproteases, and oxidants: Pathways of tissue injury during inflammation
81. A simple method for detection of functional and genetics alpha-1-antitrypsin deficiencies of human serum
82. Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1PI) and haemostatic parameters during haemodialysis
83. Plasma levels of garnulocyte elastase-alpha-1-proteinase inhibitor complex in patients with disseminated intravascular coagulation: Pathophysiologic implications
84. Plasma antiprotease screen and neutrophil-mediated platelet activation. A major role played by alpha 1 antitrypsin
85. Activated coagulation factors in various thrombotic diseases
86. Evaluation of XIa-alpha 1-antitrypsin in plasma, a contact phase-activated coagulation factor-inhibitor complex, in patients with coronary artery disease
87. Clearance of human XIa-inhibitor complexes in rats
88. Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: Major role for C1-inhibitor
89. Plasmin catalyses binding of lipoprotein(a) to immobilized fibrinogen and fibrin
90. Learning about the structure and biology of human lipoprotein(a) through dissection by enzymes of the elastase family: Facts and speculations
91. Clinical-pathological correlations of coronary disease progression and regression
92. Early stages of atherosclerosis. The morphogenesis of lipid spots in the aorta of children
93. Exogenous and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibrolast growth factor
94. Elastase and cell matrix interactions in the pathobiology of vascular disease
95. Effect of elastin peptides on cell proliferation
96. Modulation of cell proliferation by proteinase inhibitors. A new analytical approach
97. The acute-phase protein alphaI-antitrypsin inhibits transferin-receptor binding and proliferation of human skin fibroblasts
98. Further evidence for a cell surface proteinase essencial to the growth of culture fibroblasts
99. Tissue-type plasminogen activator is a potent mitogen for human aortic smooth muscle cells