NCX4016 (NO-aspirin) inhibits thromboxane biosynthesis and tissue factor expression and activity in human monocytes

Medical Science Monitor

Volumn 7, Issue 4, 2001, Pages 573-577

  Minuz, Pietro ^a,c   Degan, Maurizio ^a   Gaino, Stefania ^a   Meneguzzi, Alessandra ^a   Zuliani, Valeria ^a   Santonastaso, Clara Lechi ^a   Del Soldato, Piero ^b   Lechi, Alessandro ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b NicOx SA   (France)

^c Medicina Interna C   (Italy)

Author keywords

Acetylsalicylic acid; Cyclo oxygenase; Human monocytes; NCX4016; Nitric oxide; Thromboxane; Tissue factor

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; BLOOD CLOTTING FACTOR 7; CYCLIC GMP; NITRIC OXIDE; THROMBOPLASTIN; THROMBOXANE B2;

ARTICLE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MONOCYTE; PROTEIN EXPRESSION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ASPIRIN; HUMANS; MONOCYTES; NITRIC OXIDE DONORS; NITROSO COMPOUNDS; PLATELET AGGREGATION INHIBITORS; THROMBOPLASTIN; THROMBOXANE B2;

EID: 0034922012     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. NO-aspirins: Antithrombotic activity of derivatives of acetyl salicytic acid releasing nitric oxide
2. 2 production
3. 2 production in rats
4. In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016
5. Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin
6. Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
7. IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: New insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs
8. Characterization of 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase
9. Co-induction of nitric oxide synthase and cyclo-oxygenase: Interactions between nitric oxide and prostanoids
10. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques
11. Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes
12. Regulation of the tissue factor gene
13. The role of the tissue factor pathway in initiation of coagulation
14. Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide
15. Modification of tissue factor by peroxynitrite influences its procoagulant activity
16. Pharmacokinetics of a new nitroderivative of acetylsalicylic acid after a single dose in rats