Does reduced α1-antitrypsin activity explain the link between cigarette smoking and idiopathic pulmonary fibrosis?

Chest

Volumn 120, Issue SUPPL., 2001, Pages

  Chan, E D ^a   Ralston, A H ^a   Shapiro, L ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Nitric oxide, pulmonary fibrosis; Serine protease; Smoking; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

CIGARETTE SMOKING; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; LUNG FIBROSIS; MACROPHAGE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR;

EID: 0034921659     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0012-3692(15)38727-4     Document Type: Conference Paper

References (12)

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5. Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models
6. Role of reactive nitrogen intermediate production in alveolar macrophage-mediated cytostatic activity induced by bleomycin lung damage in rats
7. 1-Antitrypsin: Molecular pathology, leukocytes, and tissue damage
8. 1-antitrypsin deficiency
9. 1-Antitrypsin: Molecular structure and the Pi system
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11. Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFNγ and TNFα in mouse macrophages
12. 1-antitrypsin for neutrophil elastase