Naturally occurring benzodiazepines may codetermine chronotypes

Journal of Neural Transmission

Volumn 108, Issue 6, 2001, Pages 747-753

  Sand, P ^a   Kleinschnitz, M ^a   Vogel, P ^a   Kavvadias, D ^a   Schreier, P ^a   Riederer, P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Benzodiazepines; Chronotypes; GABAA mimetics; Natural products; Sleep

Indexed keywords

BENZODIAZEPINE DERIVATIVE; NATURAL PRODUCT;

ADULT; ARTICLE; CIRCADIAN RHYTHM; COMA; CONSCIOUSNESS DISORDER; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL DISEASE; MENTAL HEALTH; NORMAL HUMAN; PRIORITY JOURNAL; SLEEP DISORDER; SLEEP WAKING CYCLE;

ADULT; BENZODIAZEPINES; BIOLOGICAL CLOCKS; BRAIN CHEMISTRY; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; POLYSOMNOGRAPHY; RECEPTORS, GABA-A; SLEEP, REM; WAKEFULNESS;

EID: 0034919370     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020170049     Document Type: Article

References (27)

1. Hepatic encephalopathy: Molecular mechanisms underlying the clinical syndrome
2. Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy
3. Diagnosis and treatment of hepatic encephalopathy
4. All-night polygraphic recordings on the hypnotic effects of a new benzodiazepine: Flunitrazepam (Ro 5-4200, Rohypnol)
5. Reduction of epileptiform activity in response to low-dose clonazepam in children with epilepsy: A randomized double-blind study
6. Quantitation by gas chromatography with selectedion monitoring mass spectrometry of "natural" diazepam, N-desmethyldiazepam and oxazepam in normal human serum
7. The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans
8. Changes in cerebral receptors for gamma aminobutyric acid in patients with hepatic encephalopathy
9. Effects of three benzodiazepines (nitrazepam, flunitrazepam and bromazepam) on sleep of normal subjects, studied with an automatic sleep scoring system
10. Identification of sleep-promoting neurons in vitro
11. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms
12. A polysomnographic study of sleep patterns in normal humans with low- or high-anxiety personality traits
13. Identification of benzodiazepines in Artemisia dracunculus and Solanum tuberosum rationalizing their endogenous formation in plant tissue
14. "Natural" benzodiazepines in man
15. Role of GABAA receptors in the regulation of sleep: Initial sleep responses to peripherally administered modulators and agonists
16. GABA synchronizes clock cells within the suprachiasmatic circadian clock
17. Effects of microinjections of triazolam into the ventrolateral preoptic area on sleep in the rat
18. Flunitrazepam (Ro 5-4200) and sleep cycle in normal subjects
19. A sparse projection from the suprachiasmatic nucleus to the sleep active ventrolateral preoptic area in the rat
20. Circadian patterns of serum endogenous benzodiazepines
21. Naturally occurring benzodiazepines: Current status of research and clinical implications
22. Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain
23. The discovery of librium
24. Zinc and flunitrazepam modulation of GABA-mediated currents in rat suprachiasmatic neurons
25. Morningness/eveningness and the need for sleep
26. Occurrence of pharmacologically active benzodiazepines in trace amounts in wheat and potato