Ascorbic acid inhibits the increase in low-density lipoprotein (LDL) susceptibility to oxidation and the proportion of electronegative LDL induced by intense aerobic exercise

Coronary Artery Disease

Volumn 9, Issue 5, 1998, Pages 249-255

  Sánchez Quesada, José Luis ^a,b   Jorba, Oscar ^a   Payés, Amalia ^a   Otal, Carles ^a   Serra Grima, Ricard ^a   González Sastre, Francesc ^a,b   Ordóñez Llanos, Jordi ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Aerobic exercise; Antioxidants; Electronegative LDL; LDL oxidation

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN B; ASCORBIC ACID; LIPID PEROXIDE; LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; EXERCISE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIPID OXIDATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RUNNING;

EID: 0031856460     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-199809050-00002     Document Type: Article

References (39)

1. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320:915-924.
2. Palinski W, Rosenfeld ME, Yla-Herttuala S, Gurtner GC, Socher SA, Butler SW, et al. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA 1989; 87:1372-1376.
3. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, et al. Evidence for the presence of oxidatively modified LDL in atherosclerotic lesions of rabbit and man. J Clin Invest 1989; 84:1086-1095.
4. Maggi E, Chiesa R, Melissano G, Castellano R, Astore D, Grossi A, et al. LDL oxidation in patients with severe atherosclerosis. A study of in-vitro and in-vivo markers. Arterioscler Thromb 1994; 14:1892-1899.
5. Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A, et al. Probucol prevents the progression of atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA 1987; 84:5928-5931.
6. Rengstrom J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low denstity oxidation and coronary atherosclerosis in man. Lancet 1992; 339:1183-1186.
7. Andrews B, Burnand K, Paganga G, Browse N, Rice-Evans C, Sommerville K, et al. Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis. Atherosclerosis 1995; 112:77-84.
8. Cominacini L, Garbin U, Pastorino AM, Davoli A, Campagnola M, De Santis A et al. Predisposition to LDL oxidation in patients with and without angiographically established coronary artery disease. Atherosclerosis 1993; 99:63-70.
9. Esterbauer H, Gebicki J, Puhl H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 1992; 13:341-390.
10. Avogaro P, Bittolo Bon G, Cazzolato G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis 1988; 8:79-87.
11. Shimano H, Yamada N, Ishibashi S, Mokuno H, Mori N, Gotoda T, et al. Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography. J Lipid Res 1991; 32:763-773.
12. Vedie B, Myara I, Pech MA, Maziere JC, Maziere C, Caprani A, et al. Fractionation of charge-modified low density lipoprotein by fast protein liquid chromatography. J Lipid Res 1991; 32:1359-1369.
13. Hodis HN, Kramsch DM, Avogaro P, Bittolo-Bon G, Cazzolato G, Hwang J, et al. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL). J Lipid Res 1994; 35:669-677.
14. Demuth K, Myara I, Chappey B, Vedie B, Pech-Ansellem MA, Haberland ME, et al. A cytotoxic electronegative LDL subfraction is present in human plasma. Arterioscler Thromb Vasc Biol 1996; 16:773-783.
15. Cazzolato G, Avogaro P, Bittolo-Bon G. Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radic Biol Med 1991; 11:247-253.
16. Sevanian A, Hwang J, Hodis H, Cazzolato G, Avogaro P, Bittolo-Bon G. Contribution of an in vivo oxidized LDL to LDL oxidation and its association with dense LDL subpopulations. Arterioscler Thromb Vasc Biol 1996; 16:784-793.
17. Tertov VV, Bittolo-Bon G, Sobenin IA, Cazzolatto G, Orekhov AN, Avogaro P. Naturally occurring modified low density lipoproteins are similar if not identical: more electronegative and desialylated lipoprotein subfractions. Exp Mol Pathol 1995; 62:166-172.
18. Chappey B, Myara I, Benoir MO, Maziere C, Maziere JC, Moatti N. Characteristics of ten charge-differing subfractions isolated from human native low density lipoprotein (LDL). No evidence of peroxidative modifications. Biochim Biophys Acta 1995; 1259:261-270.
19. Berlin JA, Colditz GA. A meta-analysis of physical activity in the prevention of coronary heart disease. Am J Epidemiol 1990; 132:612-628.
20. Goldberg L, Elliot DC. The effect of exercise on lipid metabolism in men and women. Sports Med 1987; 4:307-321.
21. Beard CM, Barnard RJ, Robbins DC, Ordovas JM, Schaefer EJ. Effects of diet and exercise on qualitative and quantitative measures of LDL and its susceptibility to oxidation. Arterioscler Thromb Vasc Biol 1996; 16:201-207.
22. Sánchez-Quesada JL, Ortega H, Payés-Romero A, Serrat-Serrat J, González-Sastre F, Lasunción MA, et al. LDL from aerobically-trained subjects shows higher resistance to oxidative modification than LDL from sedentary subjects. Atherosclerosis 1997; 132:207-213.
23. Sánchez-Quesada JL, Homs-Serradesanferm R, Serrat-Serrat J, Serra-Grima JR, González-Sastre F, Ordóñez-Llanos J. Increase of LDL susceptibility to oxidation occurring after intense, long duration aerobic exercise. Atherosclerosis 1995; 118:297-305.
24. Brooks GA, Fahey T (editors). Human bioenergetics and its application. In: Exercise physiology. McMillan, New York; 1994. pp 338-364.
25. Gugluicci-Creriche A, Stahl AJC. Glycation and oxidation of human low density lipoproteins reduces heparin binding and modifies charge. Scand J Clin Lab Invest 1993; 53:125-132.
26. Sénchez-Quesada JL, Pérez A, Caixás A, Ordóñez-Llanos J, Carreras G, Payés A, et al. Electronegative low density lipoprotein subform is increased in short-duration IDDM patients and is closely related to glycaemic control. Diabetologia 1996; 39:1469-1476.
27. Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids 1987; 45:337-351.
28. Greenleaf JE, Convertino VA, Mangseth GR. Plasma volume during stress in man: osmolality and red cell volume. J Appl Physiol 1979; 47:1031-1038.
29. Hainline A, Karon J, Lippel K. Lipid research clinic program. Manual of laboratory operations; lipid and lipoprotein analysis. 2nd ed. Bethesda (MD): National, Heart. Lung and Blood Institute; 1982. HEW Publication No. 1982;(NIH):75-628 (revised). (US Government Printing Office No. 1982-361-132:678.)
30. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34:1345-1353.
31. Bradford MA. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding. Anal Biochem 1976; 72:248-254.
32. Esterbauer H, Striegl G, Puhl H, Rothender M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 1989; 6:67-75.
33. Sierra C, Pastor MC, de Ramón M. Liquid chromatography determination of α-tocopherol in erythrocytes. Clin Chim Acta 1992; 208:119-126.
34. Esterbauer H, Dieber-Rotheneder M, Striegl G, Waeg G. Role of vitamin E in preventing the oxidation of low density lipoprotein. Am J Clin Nutr 1991; 53:314S-321S.
35. Davies KJA, Quintanilha AT, Brooks GA, Packer L. Free radical and tissue damage produced by exercise. Biochim Biophys Res Commun 1982; 107:1198-1205.
36. Kanter MM, Nolte LA, Holloszy JO. Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. J Appl Physiol 1993; 74:965-969.
37. Retski KL, Freeman MW, Frei B. Ascorbic acid oxidation products protect human low density lipoprotein against atherogenic modification: anti-rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem 1993; 268:1304-1309.
38. Wayner DDM, Burton GW, Ingold KU, Locke S. Quantitative measurement of the total peroxyl radical-trapping antioxidant capability of human blood plasma by controlled lipid peroxidation. FEBS Lett 1985; 187:33-37.
39. Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for α-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 1994; 269:16712-16720.