Determination of the effects of mycophenolic acid on the nucleotide pool of human peripheral blood mononuclear cells in vitro by high-performance liquid chromatography

Clinica Chimica Acta

Volumn 310, Issue 1, 2001, Pages 81-87

  Daxecker, Heide ^a,b   Raab, Markus ^a,b   Cichna, Margit ^b   Markl, Peter ^b   Müller, Mathias M ^a  

^a KAISER FRANZ JOSEF HOSPITAL   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

High performance liquid chromatography; Ion pair chromatography; Mycophenolic acid; Nucleotides; Peripheral blood mononuclear cells; Reversed phase chromatography

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; CYTIDINE TRIPHOSPHATE; GUANINE NUCLEOTIDE; GUANOSINE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; PHYTOHEMAGGLUTININ; PREDNISOLONE; PURINE NUCLEOTIDE; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; URIDINE DIPHOSPHATE; URIDINE NUCLEOTIDE; URIDINE TRIPHOSPHATE;

ARTICLE; BLOOD; CELL ACTIVATION; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; GRAFT REJECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MOLECULAR MIMICRY; MONONUCLEAR CELL; NORMAL HUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; HUMANS; MONOCYTES; MYCOPHENOLIC ACID; NUCLEOTIDES;

EID: 0034910971     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(01)00526-5     Document Type: Article

References (12)

1. In vitro effects of mycophenolic acid on cell cycle and activation of human lymphocytes
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3. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid
4. Mechanism of action of mycophenolate mofetil
5. Mycophenolate mofetil and its mechanisms of action
6. Mycophenolic acid: A one hundred year odyssey from antibiotic to immunosuppressant
7. Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation
8. Levels and variability of purine nucleotides in normal human lymphocytes
9. Separation of nucleotides by ion-pair, reversed-phase high-performance liquid chromatography - Use of Mg(II) and triethylamine as competing hetaerons in the separation of adenine and guanine nucleotides
10. Optimized analysis of intracellular adenosine and guanosine phosphates in Escherichia coli
11. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
12. Mycophenolic acid-induced GTP depletion also affects ATP and pyrimidine synthesis in mitogen-stimulated primary human T-lymphocytes