Amphipathic control of the 310-/α-helix equilibrium in synthetic peptides

Journal of Peptide Research

Volumn 58, Issue 2, 2001, Pages 108-116

  Hammarstrom L G J ^a   Gauthier, T J ^a   Hammer, R P ^a   McLaughlin, Mark L ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

helix; 310 helix; Amphipathic peptides; C , C disubstituted glycines; CD spectroscopy; Helix equilibrium

Indexed keywords

ACETONITRILE; AMPHOPHILE; CARBOXYLIC ACID DERIVATIVE; DODECYL SULFATE SODIUM; GLYCINE; SYNTHETIC PEPTIDE; TRIFLUOROETHANOL; WATER;

ALPHA HELIX; ARTICLE; CIRCULAR DICHROISM; MICELLE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; SPECTROSCOPY; STEREOSPECIFICITY;

CIRCULAR DICHROISM; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; TEMPERATURE;

EID: 0034909395     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00858.x     Document Type: Article

References (52)

1. 10-Helix versus α-helix: A molecular dynamics study of conformational preferences of Aib and alanine
2. Controlling peptide structure
3. α-disubstituted glycines
4. 10-helix/coil and α-helix/coil theory
5. 10-helical conformation of alanine-based peptides in aqueous solution: An electron spin resonance investigation
6. 10: The split personality of polypeptide helices
7. Circular dichroism studies of helical oligopeptides
8. 10-helix
9. 10-/αhelix transition - Implications for a natural reaction coordinate
10. nOMe
11. Molecular-dynamics and Monte-Carlo simulations favor the alpha-helical form for alanine-based peptides in water
12. 10- to α-helical transition of an oligopeptide in various solvents
13. 10-helix along the thermodynamic folding pathway
14. Helix geometry in proteins
15. 10-helices and not α-helices in aqueous solution
16. + salt bridges in short peptides of de novo design
17. Unusually stable helix formation in short alanine-based peptides
18. Calormetric determination of the enthalpy change for the alpha-helix to coil transition of an alanine peptide in water
19. 10helix in peptides based on Cα-tetrasubstituted α-amino acids by main-chain to side-chain hydrogen bonds
20. 10-helical oligopeptides containing redox cyclic α-amino acids
21. 10-helical Aib-based peptides, modulated by chain-length-dependent topologies
22. The stereochemistry of peptides containing α-aminoisobutyric acid
23. Factors governing helical preference of peptides containing multiple α,α-dialkyl amino acids
24. Helical stability of de novo designed α-aminoisobutyric acid-rich peptides at high temperatures
25. Stereochemically constrained linear peptides. Conformations of peptides containing α-aminoisobutyric acid
26. Sequence and specificity of two antibacterial proteins involved in insect immunity
27. Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor
28. Isolation, amino acid sequence and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin
29. 4-Aminopiperidine-4-carboxylic acid: A cyclic α,α-disubstituted amino acid for preparation of water-soluble highly helical peptides
30. Stereochemically constrained peptides, theoretical and experimental studies on the conformations of peptides containing 1-aminocyclohexanecarboxylic acid
31. Structural characteristics of α-helical peptide molecules containing Aib residues
32. Structures of polypeptides from α-amino acids disubstituted at the α-carbon
33. Conformational analysis and helical preferences of normal and α, α-dialkyl amino acids
34. β-branched, chiral α-amino acids (αMe) Dip and [αMe) Val
35. Folding, aggregation and molecular recognition in peptides
36. 2-Phe-Aib fragment
37. Antimicrobial α, α-dialkylated amino acid rich peptides with in vivo activity against an intracellular pathogen
38. 1-tert-Butyloxycarbonyl-4(9-fluorenylmethyloxycarbonyl) amino)-piperidine-4-carboxylic acid. A convenient preparation of an orthogonally protected α,α-disubstituted amino acid analog of lysine
39. A bimetallic helical heptapeptide as a transphosphorylation catalyst in water
40. 10-helix
41. The magainins: Antimicrobial peptides with potential for topical application
42. Mode of action of linear amphipathic alpha helical antimicrobial peptides
43. 10/α-helical transition upon sequence permutation
44. 10/ α-helix transition with composition and sequence sensitivity
45. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids
46. Circular dichroism studies of α-aminoisobutyric acid-containing peptides: Chain length and solvent effects in alternating Aib-L-Ala and Aib-L-Val sequences
47. 10- and α-helical conformations be chiroptically distinguished?
48. Theoretical studies of polypeptide helices: Examination of important electronic and geometric factors
49. Minimal peptide length for interaction of amphipathic alpha-helical peptides with phosphatidylcholine liposomes
50. 10helical peptides and their interactions with phospholipid bilayers and ion channel formation
51. n