Effect of a six month gemfibrozil treatment and dietary recommendations on the metabolic risk profile of visceral obese men

International Journal of Obesity

Volumn 25, Issue 8, 2001, Pages 1136-1143

  Dumont, M ^a   Mauriege P ^a   Bergeron, J ^b   Despres J P ^b   Prud'homme, D ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Gemfibrozil; Insulin sensitivity; Lipids; Visceral obesity

Indexed keywords

APOLIPOPROTEIN B; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; PLACEBO;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NUTRITIONAL REQUIREMENT; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADIPOSE TISSUE; ANTILIPEMIC AGENTS; AREA UNDER CURVE; BLOOD GLUCOSE; CHOLESTEROL; GEMFIBROZIL; GLUCOSE TOLERANCE TEST; HUMANS; HYPERLIPIDEMIAS; INSULIN; LIPIDS; LIPOPROTEINS, HDL; MALE; MIDDLE AGED; OBESITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0034909382     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801665     Document Type: Article

References (55)

1. The Canadian consensus conference on the prevention of heart and vascular disease by altering serum cholesterol and lipoprotein risk factors
2. Epidemiology of coronary heart disease: The Framingham study
3. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease
4. Abdominal obesity and the development of non-insulin-dependent diabetes mellitus
5. 'Portal' adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
6. Biology of regional body fat distribution: Relationship to non-insulin-dependent diabetes mellitus
7. Health risks of obesity
8. Relationship of fat distribution to glucose tolerance. Results of computed tomography in male participants of the Normative Aging Study
9. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity
10. Adiposity, fat distribution, and cardiovascular risk
11. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels
12. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men
13. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women
14. Adipose tissue distribution and plasma lipoprotein levels in obese women: Importance of intra-abdominal fat
15. Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels
16. Obesity and lipid metabolism: Relevance of body fat distribution
17. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease
18. New lipid lowering drugs and new effects of old drugs
19. Helsinki heart study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia
20. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
21. Altering triglyceride concentrations changes insulin-glucose relationships in hypertriglyceridemic patients. Double-blind study with gemfibrozil with implications for atherosclerosis
22. Insulin action and glucose metabolism are improved by gemfibrozil treatment in hypertriglyceridemic patients
23. The gross composition of the body
24. Volume of the lung determined by helium dilution
25. 40K and tritium
26. Assessment of adipose tissue distribution by computed axial tomography in obese women: Association with body density and anthropometric measurements
27. Zur bestimmung der plasmaglukosekonzentration mit der hexokinase-glucose-6-phosphat-dehydrogenase-methose
28. A new colorimetric micro-determination of free fatty acids in serum
29. Plasma triglycerides related decrease in high density lipoprotein cholesterol and its association with myocardial infarction in heterozygous familial hypercholesterolemia
30. Are apolipoprotein better discriminators than lipids for atherosclerosis?
31. Specific assays for lipoprotein lipase and hepatic lipase activities of post-heparin plasma
32. Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women
33. Glucose clamp technique: A method for quantifying insulin secretion and resistance
34. The fibrates in clinical practice: Focus on micronised fenofibrate
35. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
36. Reappraisal of the role of insulin in hypertriglyceridemia
37. The assessment of hepatic and peripheral insulin sensitivity in hypertriglyceridemia
38. Hypertriglyceridemia and carbohydrate intolerance: Interrelations and therapeutic implications
39. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance
40. Resistance to insulin but not to glucagon in lean human hypertriglyceridemics
41. Influence of gemfibrozil of lipoprotein composition: Triglyceride removal capacity and fatty acid composition of the plasma lipid ester
42. Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man
43. Prospective analysis of the insulin-resistance syndrome (syndrome X)
44. Role of apolipoprotein CIII in triglyceride-rich lipoprotein metabolism
45. Lipokinetic studies with gemfibrozil
46. Inter-relationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in non-diabetic and diabetic patients with endogenous hypertriglyceridemia
47. Treatment of lipid disorders in non-insulin-dependent diabetes mellitus
48. Significance of hepatic triglyceride lipase activity in the regulation of serum high density lipoprotein in type II diabetes mellitus
49. The dyslipoproteinemia of anabolic steroid therapy: Increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein cholesterol
50. High density lipoproteins. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase
51. Lipoprotein-lipase action determining plasma high density lipoprotein cholesterol levels in adult normolipaemics
52. High density lipoprotein metabolism