Myocardial uptake and release of substrates in type II diabetics undergoing coronary surgery

Scandinavian Cardiovascular Journal

Volumn 35, Issue 3, 2001, Pages 207-211

  Szabo, Zoltân ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Beta hydroxybutyric acid; Coronary surgery; Diabetes; Free fatty acids; Glucose; Glutamate; Ketones; Myocardial metabolism

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALANINE; CARBOHYDRATE; FATTY ACID; GLUTAMIC ACID;

ADAPTATION; ADULT; ARTERY; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY SURGERY; CORONARY SINUS; ENERGY RESOURCE; ENZYME SUBSTRATE; EXTRACTION; FEMALE; HEART CATHETERIZATION; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART SURGERY; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SURGICAL TECHNIQUE;

3-HYDROXYBUTYRIC ACID; CORONARY ARTERY BYPASS; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; FEMALE; GLYCEROL; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; PERIOPERATIVE CARE; PREOPERATIVE CARE;

EID: 0034906002     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/140174301750305108     Document Type: Article

References (33)

1. Cohen Y. Raz 1. Merin G, Mozes B. Comparison of factors associated with 30day mortality after coronary artery bypass grafting in patients with versus without diabetes mcllitus. Israeli Coronary Artery Bypass (ISCAB) Study Consortium. Am J Cardiol 1998; 81:7-11.
2. Higgins TL. Estafanous FG. Loop FD. Beck GJ. Blum JM. Paranandi L. Stratification of morbidity and mortality outcome by preoperative risk factors in coronary artery bypass patients. A clinical severity score. JAMA 1992; 267: 2344-2348.
3. Stewart RD. Campos CT. Jennings B, Lollis SS. Levitsky S. Lahey SJ. Predictors of 30-day hospital readmission after coronary artery bypass. Ann Thorac Surg 2000; 70: 169-174.
4. Avogaro A, Nosadini R, Doria A, et al. Myocardial metabolism in insulindeficient diabetic humans without coronary artery disease. Am J Physiol 1990; 25S: E606-E61K.
5. Carlsten A. Hallgren B. Jagenburg R. Svanborg A. Werko L. Amino acids and free fatly acids in plasma in diabetes. II. The myocardial arterio-venous differences before and after insulin. Ada Med Scand 1966: 179: 631-639.
6. Svedjeholm R. Hàkanson E, Vanhanen I. Rationale for metabolic support with amino acids and glucose-insulin-potassium (G1K) in cardiac surgery. Ann Thorac Surg 1995: 59: S15-S22.
7. Bernt E. Bergmayer HU. L Glutamat: UV-test mit Glutamat-Dehydrogenase und NAD. In: Bergmayer HU, editor. Metoden der enzymatischen analyse. 3rd ed. Weinheini: Verlag Chemie GMBH. 1974: 1749-1753.
8. Schmidt FH. Die enzymatische bestimrnung von glukose und fructose. Klin Wochenschr 1%1: 39: 1244-1247.
9. Barthelmai W, CJ.ok R. Enzymatische besümmungen der glukose in blut, liquor und him. Klin Wochenschr 1962: 40: 585-589.
10. K). Ho RJ. Radiochemical assay of long-chain fatty acids using Ni as tracer. Analyt Biochem 1970: 36: 105-113.
11. Detre KM. Guo P. Holubkov R. el al. Coronary revascularization in diabetic patients: A comparison of Ihe randomized and observational components of the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 1999: 99: 633-640.
12. Corbincau H. Lcbreton H, Langanay T, Logeais Y. Leguerrier A. Prospective evaluation of coronary arteries: Influence on operative risk in coronary artery surgery. Eur J Cardiothorac Surg 1999: 16: 429-434.
13. Schneider DJ. Sobel BE. Determinants of coronary vascular disease in patients with type II diabetes mellilus and their therapeutic implications. Clin Cardiol 1997: 20: 433-440.
14. Regan TJ. Ahmed S. Haider B. Moschos C. Wcisse A. Diabetic eardiomyopathy: Experimental and clinical observations. Nevv Jersey Med 1994: 91: 776-778.
15. Fauvray D, Idell-Winger JA, Neely JR. Effect of ischemia on rat myocardial function and metabolism in diabetes. Circ Res 1979: 44: 322-329.
16. Taegtmeyer H. Passmore JM. Defective energy metabolism of the heart in diabetes. Lancet 1985: 1: 139-141.
17. Svedjeholm R. Svensson SE, Ekroth R, et al. Trauma metabolism and the heart: studies of heart and leg amino acid flux after cardiac surgery. Thorac Cardiovasc Surg 1990; 38: 1-5.
18. Svedjeholm R. Ekroth R, Joachimsson PO. Ronquist G. Svensson SE, Tydén H. Myocardial uptake of amino acids and other substrates in relation to myocardial oxygen consumption four hours after cardiac surgery. J Thorac Cardiovasc Surg 1991: 101: 688-694.
19. Svedjeholm R, Vanhanen I. Hakanson E. Joachimsson PC). Jorfeldt L. Nilsson L. Metabolic and hcmodynamic effects of intravenous glutamate infusion early after coronary operations. J Thorac Cardiovasc Surg 1996: 112: 1468-1477.
20. Vanhanen I. Hakanson E. Jorfeldt L. Svedjeholm R. Intravenous aspartale infusion after a coronary operation: Effects on myocardial metabolism and hemodynamie stale. Ann Thorac Surg 1998; 65: 1296-1302.
21. Svedjeholm R, HallhagenS. Ekroth R. Joachimsson PO. RonquislG. Dopamine and High-dose Insulin infusion (Glucose-Insulin-Potassiuml after a cardiac operation. Effects on myocardial metabolism. Ann Thorac Surg 1991: 5 1: 262270.
22. Kirn DK. Heincman FW, Balahan RS. Effects of heta-hydroxybutyratc on oxidative metabolism and phosphorylalion potential in canine heart in vivo. Am J Physiol 1991; 260: HI767-H1773.
23. Kjellman UW. Bjork K, Dahlin A. et al. Insulin (GIK) improves myocardial metabolism in patients during blood cardioplcgia. Scand Cardiovasc J 2000; 34(3): 321-330.
24. Rao V. Merante F, Weisel RD. et al. Insulin stimulates pyruvate dehydrogenasc and protects human ventricular cardiomyocytes from simulated ischemia. J Thorac Cardiovasc Surg 1998: 116: 485-494.
25. Borst P, Loos JA, Christ EJ. Slater EC. Uncoupling activity of long-chain fatty acids. Biochim Biophys Acta 1962; 62: 509-518.
26. Fauvray D. Idell-Winger JA. Neely JR. Effect of ischemia on rat myocardial function and metabolism in diabetes. Circ Res 1979; 44: 322-329.
27. Henderson AH. Craig RJ. Gorlin R. Sonnenblick EH. Free fatty acids and inyocardial function in perfused ral hearts. Cardiovasc Res 1970; 4: 466-472.
28. Liedtke AJ. Nellis S. Neely JR. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischémie myocardium in swine. Circ Res 1978: 43: 652-661.
29. Lopaschuk GD. Stanley WC. Glucose metabolism in the ischémie hearl. Circulation 1997: 95: 313-315.
30. Simonsen S. Kjekshus JK. The effect of free fatty acids on myocardial oxygen consumption during atrial pacing and cateeholamine infusion in man. Circulation 197X; 58: 484-491.
31. Vik-Mo H. Mjos OD. Influence of free fatty acids on myocardial oxyeen consumption and ischémie injury. Am J Cardiol 1981; 48: 361-365.
32. Svensson S, Svedjeholm R. Ekroth R. et al. Trauma metabolism and (he heart. Uptake ot substrates and effects of insulin early after cardiac operations. .1 Thorac Cardiovasc Surg 1990:99: 1063-1073.
33. Nilsson F. Insulin and glucose infusion in the early postoperative phase of cardiac surgery. Effects on systemic carbohydrate and lipid metabolism. Thesis. University of Gothenburg. 1987: 7-49.