Novel virulence and host range genes of African swine fever virus

Current Opinion in Microbiology

Volumn 4, Issue 4, 2001, Pages 456-461

  Tulman, Edan R ^a   Rock, Daniel L ^a  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN SWINE FEVER VIRUS; GENETIC ANALYSIS; MACROPHAGE; NONHUMAN; REGULATORY MECHANISM; REVIEW; VIRAL GENETICS; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS IMMUNITY; VIRUS VIRULENCE;

ACARI; AFRICAN SWINE FEVER VIRUS; CLASSICAL SWINE FEVER VIRUS; SUS SCROFA;

EID: 0034905965     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00235-6     Document Type: Review

References (46)

1. Famíly asfarviridae
2. African swine fever virus infection of the bushpig (Potamochoerus porcus) and its significance in the epidemiology of the disease
3. The pathogenesis of African swine fever in the resistant bushpig
4. African swine fever virus infection in the argasid host, Ornithodoros porcinus porcinus
5. African swine fever virus replication in the midgut epithelium is required for infection of Ornithodoros ticks
6. Analysis of the complete nucleotide sequence of African swine fever virus
7. The African swine fever virus proteins p54 and p30 are involved in two distinct steps of virus attachment and both contribute to the antibody-mediated protective immune response
8. Virus-specific cell receptors are necessary, but not sufficient, to confer cell susceptibility to African swine fever virus
9. African swine fever virus multigene family 360 and 530 genes are novel macrophage host range determinants
10. African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages
11. The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine
12. A nonessential African swine fever virus gene UK is a significant virulence determinant in domestic swine
13. An African swine fever virus virulence-associated gene NL-S with similarity to the herpes simplex virus ICP34.5 gene
14. The gamma 134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells
15. Nuclear and nucleolar localization of an African swine fever virus protein, I14L, that is similar to the herpes simplex virus-encoded virulence factor ICP34.5
16. African swine fever virus NL gene is not required for virus virulence
17. African swine fever: A disease characterized by apoptosis
18. African swine fever virus: A B cell-mitogenic virus in vivo and in vitro
19. Modulation of T cell and monocyte function in the spleen following infection of pigs with African swine fever virus
20. Apoptosis: A mechanism of cell killing and lymphoid organ impairment during acute African swine fever virus infection
21. An IκB homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages
22. African swine fever virus infection induces tumor necrosis factor alpha production: Implications in pathogenesis
23. A viral mechanism for inhibition of the cellular phosphatase calcineurin
24. Inhibition of nuclear factor kappaB activation by a virus-encoded IkappaB-like protein
25. Mechanism of inactivation of NF-κB by a viral homologue of IκB alpha. Signal-induced release of IκB alpha results in binding of the viral homologue to NF-κB
26. African swine fever virus protein A238L interacts with the cellular phosphatase calcineurin via a binding domain similar to that of NFAT
27. A conserved African swine fever virus IκB homolog, 5EL, is nonessential for growth in vitro and virulence in domestic pigs
28. Deletion of a CD2-like gene, 8-DR, from African swine fever virus affects viral infection in domestic swine
29. African swine fever virus EP153R open reading frame encodes a glycoprotein involved in the hemadsorption of infected cells
30. An African swine fever virus ORF with similarity to C-type lectins is non-essential for growth in swine macrophages in vitro and for virus virulence in domestic swine
31. The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10
32. African swine fever virus is enveloped by a two-membraned collapsed cisterna derived from the endoplasmic reticulum
33. African swine fever virus is wrapped by the endoplasmic reticulum
34. Biochemical requirements of virus wrapping by the endoplasmic reticulum: Involvement of ATP and endoplasmic reticulum calcium store during envelopment of african swine fever virus
35. Migration of mitchondria to viral assembly sites in African swine fever virus-infected cells
36. African swine fever virus protease, a new viral member of the SUMO-1-specific protease family
37. The African swine fever virus prenyltransferase is an integral membrane transgeranylgeranyl-diphosphate synthase
38. An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
39. A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation
40. An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1
41. Experimental African swine fever: Apoptosis of lymphocytes and virus replication in other cells
42. Apoptosis in lymph nodes in acute African swine fever
43. A BIR motif containing gene of African swine fever virus, 4CL, is nonessential for growth in vitro and viral virulence
44. An African swine fever virus bcl-2 homolog, 5-HL, suppresses apoptotic cell death
45. African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death
46. African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells