Detection of p53 gene mutations in human esophageal squamous cell carcinomas using a p53 yeast functional assay: Possible difference in esophageal carcinogenesis between the young and the elderly group

Clinical Cancer Research

Volumn 7, Issue 3, 2001, Pages 600-606

  Okuda, E ^a   Osugi, H ^a   Morimura, K ^a   Takada, N ^a   Takemura, M ^a   Fukushima, S ^a   Higashino, M ^a   Kinoshita, H ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ARTICLE; BIOASSAY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; FEMALE; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; PRIORITY JOURNAL; SMOKING; SQUAMOUS CELL CARCINOMA; YEAST;

AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CPG ISLANDS; ESOPHAGEAL NEOPLASMS; EXONS; FEMALE; GENES, P53; HUMANS; MALE; MIDDLE AGED; MUTATION; PLASMIDS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TIME FACTORS; YEASTS;

EID: 0034905328     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Base transitions at CpG dinucleotides in the p53 gene are common in esophageal adenocarcinoma
2. High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay
3. Environmental factors as regulators and effectors of multistep carcinogenesis
4. p53 mutations in human cancers
5. p53: At the crossroads of molecular carcinogenesis and risk assessment
6. A simple p53 functional assay for screening cell lines, blood, and tumors
7. p53 mutations in esophageal tumors from a high incidence area of China in relation to patient diet and smoking history
8. p53 gene mutations in esophageal cancer detected by polymerase chain reaction single-strand conformation polymorphism analysis
9. High prevalence of p53 protein overexpression in patients with esophageal cancer in Linxian, China and its relationship to progression and prognosis
10. p53 mutations in esophageal tumors from high-incidence areas of China
11. p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations
12. Prevalence of p53 mutations and protein expression in esophageal cancers in Southern Thailand
13. Increased expression of mutant forms of p53 oncogene in primary lung cancer
14. Expression of p53 in premalignant and malignant squamous epithelium
15. Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes
16. Screening patients for heterozygous p53 mutations using a functional assay in yeast
17. Clonality and stability of the p53 gene in human astrocytic tumor cells: Quantitative analysis of p53 gene mutations by yeast functional assay
18. High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis
19. A comparison of the joint effects of alcohol and smoking on the risk of cancer across sites in the upper aerodigestive tract
20. p53 mutations in head and neck cancer: New data and evaluation of mutational spectra
21. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
22. p53 mutation hot spot in radon-associated lung cancer
23. Molecular etiopathogenesis of esophageal cancers
24. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck
25. Comparative p53 mutational analysis of multiple primary cancers of the upper aerodigestive tract
26. Prevalence of p53 mutations in patients with squamous cell carcinoma of the esophagus
27. p53-tumor-suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan, China
28. p53 null mutations undetected by immunohistochemical staining predict a poor outcome with early-stage non-small cell lung carcinomas