Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia

Cell Death and Differentiation

Volumn 8, Issue 8, 2001, Pages 850-858

  Nishimura, Y ^a   Lemasters, J J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Blebs; Calcein; Cell death; Chemical hypoxia; Death channel; Glycine; Plasma membrane; Propidium iodide

Indexed keywords

ANION; CALCEIN; CATION; DEXTRAN; FLUORESCENT DYE; GLYCINE; ION CHANNEL; LUCIFER YELLOW; POTASSIUM CYANIDE; PROPIDIUM IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL HYPOXIA; CELL MEMBRANE; CELL NUCLEUS; CELL SWELLING; CONCENTRATION (PARAMETERS); CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENDOTHELIUM CELL; EXPOSURE; FLUOROPHORE; LIVER SINUSOID; MALE; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; NECROSIS; NONHUMAN; PREVENTION; PRIORITY JOURNAL; RAT;

CELL DEATH; CELL HYPOXIA; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FLUORESCENT DYES; GLYCINE; HUMANS; ION CHANNELS; LIVER; POTASSIUM CYANIDE;

EID: 0034903725     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400877     Document Type: Article

References (36)

1. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability
2. Plasma membrane bleb formation and rupture: A common feature of hepatocellular injury
3. Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, ischemic liver cell injury
4. Accelerated phospholipid degradation in anoxic rat hepatocytes
5. 2 to chemical hypoxic injury in rat hepatocyte
6. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes
7. Calcium dependence of bleb formation and cell death in hepatocytes
8. Apoptosis, oncosis, and necrosis. An overview of cell death
9. Colloidal lanthanum as a marker for impaired plasma membrane permeability in ischemic dog myocardium
10. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: A laser scanning confocal microscopic study
11. Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules
12. Physiological pH: Effect on posthypoxic proximal tubular injury
13. Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion
14. 2-induced injury in rat proximal tubules
15. Glycine in Carolina rinse solution reduces reperfusion injury, improves graft function, and increases graft survival after rat liver transplantation
16. Protection by Carolina rinse solution, acidotic pH, and glycine against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation
17. Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured hepatic sinusoidal endothelial cells: The pH paradox and cytoprotection by glucose, acidotic pH and glycine
18. Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury
19. Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels
20. Inhibition of nonlysosomal calcium-dependent proteolysis by glycine during anoxic injury of rat hepatocytes
21. Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes
22. Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine
23. Preservation of the liver
24. A novel cytotoxicity assay using a multi-well fluorescence scanner
25. Cytoprotection by inhibition of chloride channels: The mechanism of action of glycine and strychnine
26. Inhibitors of renal chloride transport do not block toxicant-induced chloride influx in the proximal tubule
27. + overload in the rat
28. Recovery of cultured rat neonatal myocytes from hypercontracture after chemical hypoxia
29. 2+ oscillations in cultured rat hepatocytes by chemical hypoxia
30. Alterations of cell volume regulation in the development of hepatocyte necrosis
31. Inactivation-resistant channels underlying the persistent sodium current in rat ventricular myocytes
32. + channel in cardiac muscle
33. + channel
34. Cell Volume Regulatory Mechanisms in Apoptotic Cell Death
35. Swelling, reductive stress and cell death during chemical hypoxia in hepatocytes
36. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide