Enhanced responses of spinal dorsal horn neurons to heat and cold stimuli following mild freeze injury to the skin

Journal of Neurophysiology

Volumn 86, Issue 2, 2001, Pages 986-996

  Khasabov, Sergey G ^a   Cain, David M ^a   Thong, Dinh ^a   Mantyh, Patrick W ^a   Simone, Donald A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLD INJURY; FREEZING; HEAT INJURY; HYPERALGESIA; MALE; NERVE CELL; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

EID: 0034901588     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2001.86.2.986     Document Type: Article

References (47)

1. Intense cold noxious stimulation of the rat hindpaw induces c-fos expression in lumbar spinal cord neurons
2. Effects of opioids and non-opioids on c-Fos-like immunoreactivity induced in rat lumbar spinal cord neurons by noxious heat stimulation
3. Sensitization of pain pathways in the spinal cord: Cellular mechanisms
4. Psychophysical study of stinging pain evoked by brief freezing of superficial skin and ensuing short-lasting changes in sensations of cool and cold pain
5. Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face
6. Physiological properties of the lamina I spinoparabrachial neurons in the rat
7. Physiological characterization of spinohypothalamic tract neurons in the lumbar enlargement of rats
8. Activity of trigeminothalamic neurons in medullary dorsal horn of awake monkeys trained in a thermal discrimination task
9. Latency to detection of first pain
10. Spinal neurons specifically excited by noxious or thermal stimuli: Marginal zone of the dorsal horn
11. The thermal grill illusion: Unmasking the burn of cold pain
12. Spinothalamic lumbosacral lamina I cells responsive to skin and muscle stimulation in the cat
13. Effects of systemic morphine on lamina I spinothalamic tract neurons in the cat
14. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. II. Responses to innocuous and noxious mechanical and thermal stimuli
15. Cold-induced pain and prickle in the glabrous and hairy skin
16. Responses of rat sacral spinal neurons to mechanical and noxious thermal stimulation of the tail
17. A role for spinal lamina I neurokinin-1-positive neurons in cold thermoreception in the rat
18. Responses of spinothalamic tract cells in the superficial dorsal horn of the primate lumbar spinal cord
19. Freezing cold injury
20. A comparison between the discharges of human nociceptive nerve fibres and the subject's ratings of his sensations
21. Nociceptive and thermoreceptive lamina I neurons are anatomically distinct
22. Effects of substance P on functionally identified units in cat spinal cord
23. Freezing-point of human skin
24. Responses of primate spinothalamic neurons to graded and to repeated noxious heat stimuli
25. Facilitation of the response of primate spinothalamic cells to cold and to tactile stimuli by noxious heating of the skin
26. Sensitization of rat spinal neurons to cold and to heat stimuli following a mild cold injury to the skin
27. Different patterns of hyperalgesia induced by experimental inflammation in human skin
28. Response properties of high-threshold cutaneous cold receptors in the primate
29. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: A comparison of neural events in monkey with sensory judgments in human
30. Vascular reactions of the skin to injury. Part III. Some effects of freezing, of cooling and of warming
31. Response properties of nociceptive and low-threshold neurons in rat trigeminal pars caudalis
32. Responses of spinal cord dorsal horn neurones to non-noxious and noxious cutaneous temperature changes in the spinal rat
33. Evidence for two distinct classes of unmyelinated nociceptive afferents in monkey
34. The induction of pain: An integrative review
35. Neuronal and behavioural responses in rats during noxious stimulation of the tail
36. Temporal and qualitative properties of cold pain and heat pain: A psychophysical study
37. Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensations
38. Response of cat skin mechanothermal nociceptors to cold stimulation
39. Neural mechanisms of hyperalgesia
40. Excitation of rat cutaneous nociceptors by noxious cold
41. Responses of cutaneous A-fiber nociceptors to noxious cold
42. Responses of primate spinothalamic neurons to noxious thermal stimulation of glabrous and hairy skin
43. Identification of afferent C units in intact human skin nerves
44. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: Simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers
45. Peripheral and central mechanisms of cutaneous hyperalgesia
46. Studies on pain. Observations on pain due to local cooling and on factors involved in the "cold pressor" effect
47. Excitability changes in central neurons following peripheral damage: Role of central sensitization in the pathogenesis of pain