Co-incubation of pig islet cells with spleen cells from non-obese diabetic mice causes decreased insulin release by non-T-cell- and T-cell-mediated mechanisms

Clinical and Experimental Immunology

Volumn 125, Issue 1, 2001, Pages 25-31

  You, S ^a   Rivereau, A S ^a   Gouin, E ^a   Sai P ^a  

^a UNIVERSITÉ DE NANTES   (France)

Author keywords

Antigen presenting cells; Cyclosporin A; Gadolinium; Islets; Lymphocytes; Mouse; Pig insulin release; Primary non function; T cell rejection; Xenograft

Indexed keywords

CD4 ANTIGEN; CYCLOSPORIN A; GADOLINIUM CHLORIDE; INSULIN; INTERLEUKIN 1BETA;

ANIMAL CELL; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; DIABETES MELLITUS, TYPE 1; FEMALE; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; SPLEEN; SWINE; T-LYMPHOCYTES;

EID: 0034899425     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01572.x     Document Type: Article

References (16)

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5. Primary nonfunction of islet grafts in autoimmune diabetic mice is prevented by treatment with interleukin-4 and interleukin-10
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7. Comparison of fetal pig pancreatic development in scid and nude mice
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13. Perifusion analysis of insulin secretion from specific pathogen-free large white pig islets shows satisfactory functional characteristics for xenografts in humans
14. Primary nonfunction of islet xenografts in rat recipients results from non-T-cell mediated immune response
15. Gadolinium chloride-induced macrophage blockade prevents rejection of human insulinoma cell xenograft in rats
16. The strength of cell-mediated xenograft rejection in the mouse is due to the CD4+ indirect response